Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 8, Issue 21, Pages 6095-6107Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qo01112j
Keywords
-
Categories
Funding
- NSF [CHE-1764141]
- NSFC [21873074, 21572163]
Ask authors/readers for more resources
In this study, a copper-catalyzed three-component coupling reaction was reported for the synthesis of fully substituted triazoles. Reactivities of alkyl azides and diazo compounds were controlled to enhance selectivity, particularly by introducing a ligand and adjusting stoichiometry. The use of aliphatic alkynes was crucial for achieving high selectivity and moderate to good yields.
Herein, we report a Cu-catalyzed three-component coupling reaction of alkynes, azides, and diazo compounds for the synthesis of fully substituted triazoles. The reactivities of alkyl azides and diazo compounds toward Cu-acetylide were controlled by the introduction of a ligand and the stoichiometry of azide and diazo compounds to suppress the undesired protonation or the alkyne-diazo coupling, maximizing the selectivity for the three-component coupling. Besides, the use of aliphatic alkynes was crucial for achieving high selectivity for the three-component coupling reaction. This method features mild reaction conditions, broad substrate scope, and good functional group tolerance. A variety of fully substituted triazoles and ring-fused triazoles were synthesized by this method in moderate to good yields.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available