Journal
GENES & DISEASES
Volume 8, Issue 6, Pages 769-780Publisher
ELSEVIER
DOI: 10.1016/j.gendis.2020.12.004
Keywords
Cancer metastasis; Exosomes; Extracetlular vesicles; Long noncoding RNA; Therapy; Tumor marker
Funding
- National Natural Science Foundation of China [81903032]
- National Key Research and Development Program of China [2016YFC1201800]
- China Postdoctoral Science Foundation [2020M672520]
- Youth Fund of Xiangya Hospital [2018Q011]
- Mittal Innovative Entrepreneurial Project of Central South Uni-versity [XCX20190719]
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Exosomal long non-coding RNAs play crucial roles in cancer metastasis and have the potential to serve as novel tumor markers and therapeutic targets.
Metastasis is a major challenge in the treatment of cancer. Exosomes are a class of small extracellular vesicles (EVs) that play critical roles in several human diseases, especially cancer, by transferring information (e.g., DNA, RNA, and protein) via cell-to-cell communication. Numerous recent studies have shown that exosomal long non-coding RNAs (lncRNAs) play crucial regulatory roles in cancer metastasis in the tumor microenvironment by altering the expression of several key signaling pathways and molecules. Due to their specificity and sensitivity, exosomal lncRNAs have potential as novel tumor markers and therapeutic targets in the treatment of cancer metastasis. In this review, we aim to summarize the roles of exosomal lncRNAs in cancer metastasis, the mechanisms underlying their roles, and their potential clinical applications. Copyright (C) 2020, Chongqing Medical University. Production and hosting by Elsevier B.V.
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