4.7 Review

Research progress of epigallocatechin-3-gallate (EGCG) on anti-pathogenic microbes and immune regulation activities

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

The inhibitory effects of PGG and EGCG against the SARS-CoV-2 3C-like protease

Wei-Chung Chiou et al.

Summary: The COVID-19 pandemic has caused a global health crisis, and developing effective treatments is crucial. This study investigates the role of SARS-CoV-2 3CLpro in viral replication and identifies natural compounds PGG and EGCG as potential inhibitors. The findings highlight the therapeutic potentials of PGG and EGCG for treating SARS-CoV-2 infection.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

Review Hematology

Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromes

James T. England et al.

Summary: This review compares the clinical features, diagnosis, and treatment approaches of COVID-CSS with other hematological CSS, emphasizing novel therapeutics targeting cytokines and cell signaling pathways. Comparison of inflammation markers and cytokine levels aims to establish a foundation for future diagnostic criteria of COVID-CSS.

BLOOD REVIEWS (2021)

Article Biochemistry & Molecular Biology

Evaluation of green tea polyphenols as novel corona virus (SARS CoV-2) main protease (Mpro) inhibitors - anin silicodocking and molecular dynamics simulation study

Rajesh Ghosh et al.

Summary: The study selected eight polyphenols from green tea, among which three were identified as potential inhibitors against SARS CoV-2 Mpro, showing promise as drug candidates for COVID-19 treatment.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Article Biochemistry & Molecular Biology

Protease targeted COVID-19 drug discovery and its challenges: Insight into viral main protease (Mpro) and papain-like protease (PLpro) inhibitors

Sk. Abdul Amin et al.

Summary: This study focuses on the potential drug discovery for COVID-19 caused by SARS-CoV-2, specifically targeting viral protease enzymes. Challenges in developing effective protease inhibitors are discussed, with emphasis on the importance of oral delivery and optimizing pharmacokinetic properties for drug development. Combining adequate pharmacokinetic properties with coronavirus protease activity and selectivity may offer potential drug candidates in the future.

BIOORGANIC & MEDICINAL CHEMISTRY (2021)

Article Medicine, General & Internal

Effects of epigallocatechin-3-gallate and acyclovir on herpes simplex virus type 1 infection in oral epithelial cells

Ching-Yi Wu et al.

Summary: The combined effects of EGCG and ACV show additive effects on reducing cytotoxicity, viral yields, and viral protein expression during HSV-1 infection in oral epithelial cells. Additionally, EGCG reduces viral particles and DNA levels during viral entry phase, while ACV can reduce the activation of c-Jun N-terminal kinase induced by HSV-1.

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION (2021)

Article Biochemistry & Molecular Biology

Immune determinants of COVID-19 disease presentation and severity

Petter Brodin

Summary: The severity of COVID-19 varies by sex and age, and is linked to comorbidities. Differences in immune reactions may go some way to explain this.

NATURE MEDICINE (2021)

Review Immunology

Influenza infection, SARS, MERS and COVID-19: Cytokine storm - The common denominator and the lessons to be learned

Varvara A. Ryabkova et al.

Summary: The review suggests that lessons from immunomodulatory therapy of COVID-19 can be applied to severe influenza infection and future outbreaks of severe respiratory viral infections, including the choice of immunomodulatory drugs, patient selection, and timing of therapy.

CLINICAL IMMUNOLOGY (2021)

Article Infectious Diseases

Inactivation of SARS-CoV-2 by Catechins from Green Tea

Hidekazu Nishimura et al.

Summary: Green tea extracts effectively inactivated SARS-CoV-2 in vitro in a dose-dependent manner, reducing viral titers significantly. Pre-infection treatment with the extract did not affect viral growth, and host cell viability was not compromised by the treatment. This suggests that catechins in green tea have the potential to suppress SARS-CoV-2 infection.

JAPANESE JOURNAL OF INFECTIOUS DISEASES (2021)

Review Biochemistry & Molecular Biology

EGCG, a Green Tea Catechin, as a Potential Therapeutic Agent for Symptomatic and Asymptomatic SARS-CoV-2 Infection

Mukesh Chourasia et al.

Summary: COVID-19, caused by SARS-CoV-2, is a global threat with vaccination efficacy still uncertain. Repurposing existing drugs targeting inflammation is gaining attention. Drugs for rheumatoid arthritis may lower COVID-19 morbidity. Study on catechins binding to viral proteins shows potential therapeutic effect.

MOLECULES (2021)

Article Biochemistry & Molecular Biology

Epigallocatechin-3-gallate, an active ingredient of Traditional Chinese Medicines, inhibits the 3CLpro activity of SARS-CoV-2

Ashuai Du et al.

Summary: SARS-CoV-2 main protease 3CLpro is an attractive antiviral target, and epigallocatechin-3-gallate (EGCG) from Chinese herbal medicine (CHM) has been identified as a potent inhibitor of 3CLpro. Multiple strategies were used to screen inhibitors from traditional Chinese medicines, and the study provides critical insights into the potential therapeutic effect of EGCG against COVID-19.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Immunology

The first 12 months of COVID-19: a timeline of immunological insights

Thiago Carvalho et al.

Summary: The timeline of major scientific discoveries during the first year of the COVID-19 pandemic highlights the collaborative efforts that led to rapid progress in understanding the immune response to SARS-CoV-2. It showcases the unprecedented convergence of research efforts on COVID-19 and identifies gaps in knowledge for future investigations.

NATURE REVIEWS IMMUNOLOGY (2021)

Article Chemistry, Multidisciplinary

ERK1/2-HNF4α axis is involved in epigallocatechin-3-gallate inhibition of HBV replication

Zi-yu Wang et al.

ACTA PHARMACOLOGICA SINICA (2020)

Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

Article Multidisciplinary Sciences

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Jerome Hadjadj et al.

SCIENCE (2020)

Review Chemistry, Multidisciplinary

Advanced Nanovehicles-Enabled Delivery Systems of Epigallocatechin Gallate for Cancer Therapy

Kai Li et al.

FRONTIERS IN CHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Can Natural Polyphenols Help in Reducing Cytokine Storm in COVID-19 Patients?

Giovanna Giovinazzo et al.

MOLECULES (2020)

Review Food Science & Technology

Nano- and micro-particles for delivery of catechins: Physical and biological performance

Jian-Hui Ye et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2019)

Review Food Science & Technology

Interactions of tea catechins with intestinal microbiota and their implication for human health

Tongtong Guo et al.

FOOD SCIENCE AND BIOTECHNOLOGY (2019)

Editorial Material Immunology

Emerging and Reemerging Infectious Diseases: Global Overview Preface

Alimuddin Zumla et al.

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (2019)

Review Microbiology

The role of the microbiota in infectious diseases

Josie Libertucci et al.

NATURE MICROBIOLOGY (2019)

Review Microbiology

Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection

Lucy C. K. Bell et al.

NATURE REVIEWS MICROBIOLOGY (2018)

Review Microbiology

Metabolic principles of persistence and pathogenicity in Mycobacterium tuberculosis

Sabine Ehrt et al.

NATURE REVIEWS MICROBIOLOGY (2018)

Review Microbiology

Ecology and evolution of Mycobacterium tuberculosis

Sebastien Gagneux

NATURE REVIEWS MICROBIOLOGY (2018)

Review Medicine, Legal

The safety of green tea and green tea extract consumption in adults - Results of a systematic review

Jiang Hu et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2018)

Review Biochemistry & Molecular Biology

Bioavailability of Tea Catechins and Its Improvement

Zhuo-Yu Cai et al.

MOLECULES (2018)

Review Critical Care Medicine

Global Epidemiology of Tuberculosis

Philippe Glaziou et al.

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

Article Integrative & Complementary Medicine

Epigallocatechin gallate inhibits hepatitis B virus infection in human liver chimeric mice

Yu-Heng Lai et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2018)

Article Biochemistry & Molecular Biology

Epigallocatechin gallate, an active green tea compound inhibits the Zika virus entry into host cells via binding the envelope protein

Nitin Sharma et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

Review Food Science & Technology

Food macromolecule based nanodelivery systems for enhancing the bioavailability of polyphenols

Bing Hu et al.

JOURNAL OF FOOD AND DRUG ANALYSIS (2017)

Review Immunology

The role of oxidative stress in influenza virus infection

Miaomiao Liu et al.

MICROBES AND INFECTION (2017)

Review Oncology

Oxidative stress-induced diseases and tea polyphenols

Xiangbing Mao et al.

ONCOTARGET (2017)

Article Gastroenterology & Hepatology

EGCG Maintains Th1/Th2 Balance and Mitigates Ulcerative Colitis Induced by Dextran Sulfate Sodium through TLR4/MyD88/NF-κB Signaling Pathway in Rats

Xue Bing et al.

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2017)

Article Integrative & Complementary Medicine

Epigallocatechin-3-gallate Prevents Triptolide-Induced Hepatic Injury by Restoring the Th17/Treg Balance in Mice

Shu-Jing Yu et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2016)

Article Immunology

Virus and Host Testing to Manage Chronic Hepatitis B

Grace Lai-Hung Wong et al.

CLINICAL INFECTIOUS DISEASES (2016)

Review Chemistry, Medicinal

Therapeutic effects of EGCG: a patent review

Leewanshi Chakrawarti et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2016)

Review Infectious Diseases

Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis

Ameeruddin Nusrath Unissa et al.

INFECTION GENETICS AND EVOLUTION (2016)

Article Medicine, General & Internal

Green tea EGCG, T-cell function, and T-cell-mediated autoimmune encephalomyelitis

Dayong Wu

JOURNAL OF INVESTIGATIVE MEDICINE (2016)

Article Immunology

Immunity by equilibrium

Gerard Eberl

NATURE REVIEWS IMMUNOLOGY (2016)

Article Public, Environmental & Occupational Health

Impact of tea drinking upon tuberculosis: a neglected issue

Mengshi Chen et al.

BMC PUBLIC HEALTH (2015)

Review Pharmacology & Pharmacy

Narrow therapeutic index drugs: a clinical pharmacological consideration to flecainide

Juan Tamargo et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2015)

Article Respiratory System

Influenza virus-induced lung injury: pathogenesis and implications for treatment

Susanne Herold et al.

EUROPEAN RESPIRATORY JOURNAL (2015)

Article Chemistry, Analytical

Catechin inhibition of influenza neuraminidase and its molecular basis with mass spectrometry

Patrick Mueller et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2015)

Article Virology

Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action

Noemie Calland et al.

JOURNAL OF VIROLOGY (2015)

Article Biochemical Research Methods

Simultaneous detection of green tea catechins and gallic acid in human serum after ingestion of green tea tablets using ion-pair high-performance liquid chromatography with electrochemical detection

Keiko Narumi et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2014)

Review Biochemistry & Molecular Biology

Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals

Shu Wang et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2014)

Article Pharmacology & Pharmacy

Inhibition of influenza virus internalization by (-)-epigallocatechin-3-gallate

Meehyein Kim et al.

ANTIVIRAL RESEARCH (2013)

Review Pharmacology & Pharmacy

Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea

J. Steinmann et al.

BRITISH JOURNAL OF PHARMACOLOGY (2013)

Review Biotechnology & Applied Microbiology

Role of oxidative stress in infectious diseases. A review

Miroslav Pohanka

FOLIA MICROBIOLOGICA (2013)

Article Agriculture, Multidisciplinary

Bioactive Peptides/Chitosan Nanoparticles Enhance Cellular Antioxidant Activity of (-)-Epigallocatechin-3-gallate

Bing Hu et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2013)

Review Biochemistry & Molecular Biology

Immunomodulating effects of epigallocatechin-3-gallate from green tea: mechanisms and applications

Munkyong Pae et al.

FOOD & FUNCTION (2013)

Review Immunology

CD4(+)T Cells: Differentiation and Functions

Rishi Vishal Luckheeram et al.

CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2012)

Article Gastroenterology & Hepatology

(-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry

Noemie Calland et al.

HEPATOLOGY (2012)

Article Integrative & Complementary Medicine

Effects of Green Tea Catechins and Theanine on Preventing Influenza Infection among Healthcare Workers: A Randomized Controlled Trial

Keiji Matsumoto et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2011)

Article Gastroenterology & Hepatology

The Green Tea Polyphenol, Epigallocatechin-3-Gallate, Inhibits Hepatitis C Virus Entry

Sandra Ciesek et al.

HEPATOLOGY (2011)

Article Immunology

Catechin inhibits adhesion and migration of peripheral blood B cells by blocking CD11b

Kazushige Kawai et al.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2011)

Review Biochemistry & Molecular Biology

Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises?

Derliz Mereles et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2011)

Article Gastroenterology & Hepatology

Epigallocatechin gallate inhibits HBV DNA synthesis in a viral replication - inducible cell line

Wei He et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2011)

Review Immunology

Differentiation of Effector CD4 T Cell Populations

Jinfang Zhu et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 28 (2010)

Review Infectious Diseases

Molecular genetics of HBV infection

Stephen Locarnini et al.

ANTIVIRAL THERAPY (2010)

Review Immunology

Innate immunity and inflammation - two facets of the same anti-infectious reaction

M. Si-Tahar et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2009)

Article Biochemistry & Molecular Biology

Green tea EGCG suppresses T cell proliferation through impairment of IL-2/IL-2 receptor signaling

Dayong Wu et al.

FREE RADICAL BIOLOGY AND MEDICINE (2009)

Article Biochemistry & Molecular Biology

Tea polyphenols exerts anti-hepatitis B virus effects in a stably HBV-transfected cell line

Pian Ye et al.

JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES (2009)

Article Microbiology

Epigallocatechin gallate inactivates clinical isolates of herpes simplex virus

Charles E. Isaacs et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)

Review Biochemistry & Molecular Biology

Are polyphenols antioxidants or pro-oxidants?: What do we learn from cell culture and in vivo studies?

Barry Halliwell

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2008)

Article Biochemistry & Molecular Biology

Combined effect of epigallocatechin gallate and triclosan on enoyl-ACP reductase of Mycobacterium tuberculosis

Shailendra Kumar Sharma et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Review Public, Environmental & Occupational Health

Safety of green tea extracts - A systematic review by the US Pharmacopeia

Dandapantula N. Sarma et al.

DRUG SAFETY (2008)

Review Multidisciplinary Sciences

An ecological and evolutionary perspective on human-microbe mutualism and disease

Les Dethlefsen et al.

NATURE (2007)

Article Biochemistry & Molecular Biology

Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins

G Galati et al.

FREE RADICAL BIOLOGY AND MEDICINE (2006)

Article Biochemistry & Molecular Biology

Green tea polyphenol inhibits Mycobacterium tuberculosis survival within human macrophages

PK Anand et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2006)

Article Food Science & Technology

Comparison of the antioxidant activity of roasted tea with green, oolong, and black teas

E Satoh et al.

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2005)

Article Pharmacology & Pharmacy

Antiviral effect of catechins in green tea on influenza virus

JM Song et al.

ANTIVIRAL RESEARCH (2005)

Article Allergy

Epigallocatechin gallate attenuates adhesion and migration of CD8+ T cells by binding to CD11b

K Kawai et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2004)

Article Medicine, Research & Experimental

A single ascending dose study of epigallocatechin gallate in healthy volunteers

U Ullmann et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2003)

Article Multidisciplinary Sciences

Minimum molecular architectures for transcription and replication of the influenza virus

A Honda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Integrative & Complementary Medicine

In vitro immunomodulatory effects of ten commonly used herbs on murine lymphocytes

C Wilasrusmee et al.

JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE (2002)

Review Biochemistry & Molecular Biology

Hijacking the host: survival of pathogenic mycobacteria inside macrophages

J Pieters et al.

TRENDS IN MICROBIOLOGY (2002)