Multiple Sclerosis Therapy Consensus Group (MSTCG): position statement on disease-modifying therapies for multiple sclerosis (white paper)

Multiple sclerosis is a complex, autoimmune-mediated disease of the central nervous system characterized by inflammatory demyelination and axonal/neuronal damage. The approval of various disease-modifying therapies and our increased understanding of disease mechanisms and evolution in recent years have significantly changed the prognosis and course of the disease. This update of the Multiple Sclerosis Therapy Consensus Group treatment recommendation focuses on the most important recommendations for disease-modifying therapies of multiple sclerosis in 2021. Our recommendations are based on current scientific evidence and apply to those medications approved in wide parts of Europe, particularly German-speaking countries (Germany, Austria, and Switzerland).

Automated summary

The article discusses multiple sclerosis as a complex autoimmune disease of the central nervous system, highlighting the recent approval of disease-modifying therapies and increased understanding of disease mechanisms that have significantly altered the prognosis and course of the disease. The update from the Multiple Sclerosis Therapy Consensus Group focuses on the most important recommendations for disease-modifying therapies of multiple sclerosis in 2021, based on current scientific evidence and applicable to wide parts of Europe, particularly German-speaking countries.