Journal
SOFT MATTER
Volume 17, Issue 38, Pages 8590-8594Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1sm01221e
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Funding
- NIH [CA142746, CA252364]
- NSF [DMR-2011846, PREM-1827820]
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This study demonstrates novel enzyme triggers, phosphonaphthyl (pNP) and phosphobiphenyl (pBP) motifs, which act faster than phosphotyrosine for enzymatic self-assembly and hydrogelation.
Enzyme-instructed self-assembly (EISA) and hydrogelation is a versatile approach for generating soft materials. Most of the substrates for alkaline phosphatase catalysed EISA utilize phosphotyrosine ((p)Tyr) as the enzymatic trigger for EISA and hydrogelation. Here we show the first example of phosphonaphthyl (pNP) and phosphobiphenyl (pBP) motifs acting as faster enzymatic triggers than phosphotyrosine for EISA and hydrogelation. This work illustrates novel enzyme triggers for rapid enzymatic self-assembly and hydrogelation.
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