Journal
ANTIOXIDANTS
Volume 10, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/antiox10091352
Keywords
adipokines; antioxidant; anti-inflammatory; bilirubin; obesity; overweight
Funding
- Slovenian Research Agency [J3 8209, P1 0386, P3 0067]
- University of Primorska, Faculty of Health Sciences
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This review paper discusses the relationship between obesity and bilirubin, highlighting that obese patients typically have lower serum bilirubin levels as bilirubin is a potent antioxidant molecule that helps alleviate inflammation. The study also proposes potential strategies to increase serum bilirubin levels in obese patients.
Obesity is a chronic condition involving low-grade inflammation and increased oxidative stress; thus, obese and overweight people have lower values of serum bilirubin. Essentially, bilirubin is a potent endogenous antioxidant molecule with anti-inflammatory, immunomodulatory, antithrombotic, and endocrine properties. This review paper presents the interplay between obesity-related pathological processes and bilirubin, with a focus on adipose tissue and adipokines. We discuss potential strategies to mildly increase serum bilirubin levels in obese patients as an adjunctive therapeutic approach.
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