Journal
EUROPEAN JOURNAL OF HUMAN GENETICS
Volume 25, Issue 10, Pages 1162-1164Publisher
SPRINGERNATURE
DOI: 10.1038/ejhg.2017.114
Keywords
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Funding
- Wellcome Trust
- Sigrid Juselius Foundation
- National Institutes of Health Research (NIHR) [NIHR-HCS-D12-03-04] Funding Source: National Institutes of Health Research (NIHR)
- Medical Research Council [G0800674, G0700718] Funding Source: researchfish
- National Institute for Health Research [NIHR-HCS-D12-03-04] Funding Source: researchfish
- MRC [G0700718, G0800674] Funding Source: UKRI
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The reproductive success of men with mitochondrial disease is to date unreported. We compared the age- and era-adjusted reproductive success of 94 British male patients with mitochondrial disease to that of the UK general male population. The reproductive success of men with mitochondrial disease was 65% of that in the general population (95% confidence interval: 53%; 79%), and the effect magnitude was related to the disease severity. This contrasts with the two previous studies finding that the reproductive success of women with mitochondrial DNA disease is not impaired. We conclude that the reproductive health of men with mitochondrial disease merits increased clinical attention.
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