Journal
POLYMER CHEMISTRY
Volume 12, Issue 37, Pages 5279-5282Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1py01052b
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Sequence-defined poly(amino phosphodiester)s with main-chain tertiary amines were synthesized using automated solid-phase phosphoramidite chemistry. The polymers were characterized by HPLC and mass spectrometry, demonstrating the preparation of molecularly-defined polymers. The presence of tertiary amines in the polymer backbones facilitates sequencing by tandem mass spectrometry.
Sequence-defined poly(amino phosphodiester)s containing main-chain tertiary amines were synthesized by automated solid-phase phosphoramidite chemistry. These polymers were prepared using four monomers with different substituents. The formed polymers were characterized by HPLC and mass spectrometry. These methods evidenced preparation of molecularly-defined polymers. Furthermore, the presence of tertiary amines in the polymer backbones facilitates sequencing by tandem mass spectrometry.
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