The aluminium-[18F]fuoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules (vol 6, 30, 2021)

Summary: The [F-18]AlF radiolabelling method, which combines the favorable decay characteristics of fluorine-18 with the convenience of metal-based radiochemistry, has been widely implemented in the development of radiopharmaceuticals for the clinic. This review captures the current status of [F-18]AlF-based technology and reflects on its impact on nuclear medicine, providing insights into the future prospects of this unique radiolabelling method.