Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 8, Issue 22, Pages 6182-6186Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qo01190a
Keywords
-
Categories
Funding
- Undergraduate Innovation Research Program of Nankai University [202010055098, 202110055096]
- National Natural Science Foundation of China (NSFC) [82003186, 82073691]
- Key Research and Development Program of Tianjin City [19YFZCSY00160]
- Ningbo Science and Technology Bureau under CM2025 Programme [2020Z092]
Ask authors/readers for more resources
The study demonstrates a robust and facile method for desulfonation to achieve secondary amines, using diphenylphosphine as a catalyst. Aromatic and aliphatic sulfonamides were cleanly converted to the required amines with good to excellent chemical yields in a rapid reaction time. The functional groups tested were generally well tolerated.
In this study, a robust and facile method for desulfonation to achieve secondary amines is demonstrated. Diphenylphosphine (Ph2PH) was shown to significantly expedite the cleavage of sulfonamides under basic conditions. Aromatic and aliphatic sulfonamides were cleanly converted, with a rapid reaction time, into the required amines with good to excellent chemical yields. Moreover, the functional groups tested were generally well tolerated.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
