Journal
POLYMER CHEMISTRY
Volume 12, Issue 41, Pages 5902-5930Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1py00988e
Keywords
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Categories
Funding
- Marine Biotechnology ERA-NET project BLUETEETH - Portuguese Foundation for Science and Technology (FCT) under EU FP7 [ERA-MBT/0002/2015, 604814]
- Programa Operacional Regional do Centro-Centro 2020, in the component FEDER
- national funds (OE) through FCT/MCTES [PTDC/QUI-OUT/30658/2017, CENTRO-01-0145-FEDER-030658]
- FCT/MCTES [UIDB/50011/2020, UIDP/50011/2020]
- Spanish Ministry of Science and Innovation [RTI2018-102212-B-I00]
- Xunta de Galicia [ED431C 2018/30]
- Xunta de Galicia (Centro singular de investigacion de Galicia accreditation 2019-2022) [ED431G2019/03]
- Axencia Galega de Innovacion [IN845D 2020/09]
- European Union (European Regional Development Fund-ERDF)
- FCT [2020.04408.BD, 2020.00758.CEECIND]
- Fundação para a Ciência e a Tecnologia [2020.04408.BD, ERA-MBT/0002/2015, PTDC/QUI-OUT/30658/2017] Funding Source: FCT
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Dendrimers are powerful synthetic macromolecular architectures with unique features, but issues of cytotoxicity can be addressed by chemical functionalization and incorporation within supramolecular Layer-by-Layer (LbL) assemblies. These multifunctional LbL nanoensembles show potential for a wide range of bioapplications.
Dendrimers are powerful synthetic macromolecular architectures for a wide variety of bioapplications owing to their unique and superior features, including monodispersity, well-defined and highly branched architecture, multivalency, tunable size and shape, good water solubility, bioavailability, and precisely controllable size at the nanometer-scale. However, the cationic and higher generation dendrimers have generally proven to raise cytotoxicity concerns, which leads to the disruption of cell membranes and cell death, thus extensively limiting their use. Hence, the chemical functionalization of dendrimers' surface with desired functional moieties and their incorporation within supramolecular Layer-by-Layer (LbL) assemblies has been reported as an effective strategy to circumvent the safety issues and improve their biological performance. Herein, we systematically review the multitude of intermolecular interactions behind the build-up of supramolecular dendrimer-containing multifunctional LbL nanoensembles with improved properties and enhanced functionalities for being used in a wide variety of bioapplications. We envisage that such diversity of intermolecular interactions may increase the number of building blocks that can be combined with dendrimers and processed into robust supramolecular multifunctional nanoarchitectures across multiple length scales well-suited to be applied in biological and biomedical scenarios, including in controlled drug/therapeutics/nucleic acid delivery, gene therapy, biosensing, bioimaging, and tissue engineering and regenerative medicine. The review also provides a glimpse on the integration of the bottom-up LbL assembly technology with other bottom-up or top-down approaches for shaping increasingly complex and sophisticated dendrimer-based supramolecular multifunctional devices with high capability for being translated into practical bioapplications.
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