4.6 Article

The Rotterdam Study: 2018 update on objectives, design and main results

Journal

EUROPEAN JOURNAL OF EPIDEMIOLOGY
Volume 32, Issue 9, Pages 807-850

Publisher

SPRINGER
DOI: 10.1007/s10654-017-0321-4

Keywords

Biomarkers; Cardiovascular diseases; Cohort study; Dermatological diseases; Endocrine diseases; Epidemiologic methods; Genetic epidemiology; Liver diseases; Neurological diseases; Oncology; Ophthalmic diseases; Otolaryngological diseases; Pharmacoepidemiology; Renal diseases; Psychiatric diseases; Respiratory diseases

Funding

  1. Erasmus MC University Medical Center
  2. Erasmus University Rotterdam
  3. Netherlands Organisation for Scientific Research (NWO)
  4. Netherlands Organisation for Health Research and Development (ZonMw)
  5. Research Institute for Diseases in the Elderly (RIDE)
  6. Netherlands Genomics Initiative (NGI)
  7. Ministry of Education, Culture and Science
  8. Ministry of Health, Welfare and Sports
  9. European Commission (DG XII)
  10. Municipality of Rotterdam

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The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. Since 2016, the cohort is being expanded by persons aged 40 years and over. The findings of the Rotterdam Study have been presented in over 1500 research articles and reports (see www. erasmus-epidemiology.nl/rotterdamstudy). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.

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