Revealing the Correlation between Altered Skin Lipids Composition and Skin Disorders

Human skin layers serve as a barrier between the body and the environment, by preventing water loss and blocking the entry of chemicals, allergens, and microbes. Recent data showed that skin lipids are vital 'key players' of several functions and mechanisms performing in the skin, such as, barrier function and microbiome composition. Abnormalities in lipid composition have been observed in inflammatory cutaneous diseases with a disrupted skin barrier. This review aims to demonstrate the fundamental role of keratinocytes, sebocytes, and microbiome-derived lipids in the maintenance of the skin barrier. Furthermore, it would reveal the correlation between altered skin lipids' composition, microbiome, and the occurrence of certain dermatological disorders such as acne vulgaris, atopic dermatitis, psoriasis, and rosacea.

Automated summary

Human skin layers act as a barrier to prevent water loss and block the entry of chemicals, allergens, and microbes. Skin lipids play a crucial role in maintaining skin function and microbiome composition, and abnormalities in lipid composition can lead to inflammatory skin diseases. The correlation between altered skin lipids' composition, microbiome, and the occurrence of dermatological disorders such as acne vulgaris, atopic dermatitis, psoriasis, and rosacea is revealed in this review.