Journal
BIOMEDICAL JOURNAL
Volume 44, Issue 4, Pages 433-438Publisher
ELSEVIER
DOI: 10.1016/j.bj.2020.10.009
Keywords
Antibody avidity assay; Antibody; ELISA
Funding
- Sao Paulo Research Foundation (FAPESP) [12/15568-0, 13/11147-2, 14/11172-0, 14/07182-0, 18/04202-0, 18/17945-1, 19/02042-9]
- National Council for Scientific and Technological Development [132743/2014-6, 131412/2019-1]
- Coordination of Improvement of Post-Graduate Level Personnel (CAPES)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [12/15568-0, 19/02042-9] Funding Source: FAPESP
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Antibody avidity is a crucial parameter for evaluating immune response and distinguishing different infection statuses, with the most common method being a modified ELISA. The use of commercial kits or in-house methods to assess antibody avidity is increasing, but the lack of standardization between different assays can lead to variability in results.
Antibody avidity is an important parameter to evaluate immune response, being useful to evaluate vaccine responses and helping to distinguish acute and latent infection. The antibody avidity can be measured by different methods, yet the most common is a modified ELISA. The utilization of commercial kits or in-house methods to evaluate antibody avidity have been adopted more and more, although the lack of standardization between different assays may generate a lot of variation in the process, making it hard to compare the results generated.
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