3D-printed saw guides for lower arm osteotomy, a comparison between a synthetic CT and CT-based workflow

BackgroundThree-dimensional (3D)-printed saw guides are frequently used to optimize osteotomy results and are usually designed based on computed tomography (CT), despite the radiation burden, as radiation-less alternatives like magnetic resonance imaging (MRI) have inferior bone visualization capabilities. This study investigated the usability of MR-based synthetic-CT (sCT), a novel radiation-less bone visualization technique for 3D planning and design of patient-specific saw guides.MethodsEight human cadaveric lower arms (mean age: 78y) received MRI and CT scans as well as high-resolution micro-CT. From the MRI scans, sCT were generated using a conditional generative adversarial network. Digital 3D bone surface models based on the sCT and general CT were compared to the surface model from the micro-CT that was used as ground truth for image resolution. From both the sCT and CT digital bone models saw guides were designed and 3D-printed in nylon for one proximal and one distal bone position for each radius and ulna. Six blinded observers placed these saw guides as accurately as possible on dissected bones. The position of each guide was assessed by optical 3D-scanning of each bone with positioned saw guide and compared to the preplanning. Eight placement errors were evaluated: three translational errors (along each axis), three rotational errors (around each axis), a total translation (T) and a total rotation error (R).ResultsSurface models derived from micro-CT were on average smaller than sCT and CT-based models with average differences of 0.270.30mm for sCT and 0.24 +/- 0.12mm for CT. No statistically significant positioning differences on the bones were found between sCT- and CT-based saw guides for any axis specific translational or rotational errors nor between the T (p =.284) and R (p =.216). On Bland-Altman plots, the T and R limits of agreement (LoA) were within the inter-observer variability LoA.Conclusions This research showed a similar error for sCT and CT digital surface models when comparing to ground truth micro-CT models. Additionally, the saw guide study showed equivalent CT- and sCT-based saw guide placement errors. Therefore, MRI-based synthetic CT is a promising radiation-less alternative to CT for the creation of patient-specific osteotomy surgical saw guides.

Automated summary

The study demonstrated that the use of MRI-based synthetic CT for patient-specific osteotomy surgical saw guides showed similar results to traditional CT, both in the generation of digital surface models and in the placement of the saw guides.