Metal Cation Triggered Peptide Hydrogels and Their Application in Food Freshness Monitoring and Dye Adsorption

Metal-ligand interactions have emerged as an important tool to trigger and modulate self-assembly, and to tune the properties of the final supramolecular materials. Herein, we report the metal-cation induced self-assembly of a pyrene-peptide conjugate to form hydrogels. The peptide has been rationally designed to favor the formation of beta-sheet 1D assemblies and metal coordination through the Glu side chains. We studied in detail the self-assembly process in the presence of H+, Li+, Na+, K+, Ca2+, Ni2+, Cu2+, Zn2+, Cd2+, Co2+, Fe3+, and Cr3+ and found that the morphology and mechanical properties of the hydrogels are ion-dependent. Moreover, thanks to the presence of the metal, new applications could be explored. Cu2+ metallogels could be used for amine sensing and meat freshness monitoring, while Zn2+ metallogels showed good selectivity for cationic dye adsorption and separation.

Automated summary

Metal-cation induced self-assembly of a pyrene-peptide conjugate can form hydrogels with different morphology and mechanical properties depending on the type of metal ions present. The presence of metal ions also opens up new applications, such as using Cu2+ metallogels for amine sensing and meat freshness monitoring, and Zn2+ metallogels for cationic dye adsorption and separation.