Placental histopathology after SARS-CoV-2 infection in pregnancy: a systematic review and meta-analysis

Article Obstetrics & Gynecology

Considerations on COVID-19 pregnancy: a cases series during outbreak in Bergamo Province, North Italy

Paola Algeri et al.

Summary: This study investigated the characteristics of COVID-19 in pregnant women and found that fever and low oxygen saturation levels were common symptoms. Some cases also experienced neurological complications.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2022)

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Letter Obstetrics & Gynecology

Proposal for radiologic diagnosis and follow-up of COVID-19 in pregnant women

Luigi Carbone et al.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2022)

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Article Pathology

Histopathology of Third Trimester Placenta from SARS-CoV-2-Positive Women

Mai He et al.

Summary: The study found that the maternal SARS-CoV-2 status does not have a significant effect on placental pathology, both in terms of pathological features and symptoms.

FETAL AND PEDIATRIC PATHOLOGY (2022)

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Article Obstetrics & Gynecology

Women perception of SARS-CoV-2 vaccination during pregnancy and subsequent maternal anxiety: a prospective observational study

Ilenia Mappa et al.

Summary: The majority of pregnant women in Italy have a positive attitude towards the SARS-CoV-2 vaccine. However, vaccine campaigns seem to increase maternal anxiety levels, with a more pronounced increase among those with a negative attitude toward the vaccine.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2022)

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Review Obstetrics & Gynecology

SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis

Agustin Conde-Agudelo et al.

Summary: There is a significant association between SARS-CoV-2 infection during pregnancy and the risk of preeclampsia, with infected pregnant women having a higher likelihood of developing the condition.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2022)

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Article Immunology

Perinatal Transmission of 2019 Coronavirus Disease-Associated Severe Acute Respiratory Syndrome Coronavirus 2: Should We Worry?

Cuifang Fan et al.

Summary: This report presents two cases of COVID-19-associated severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the third trimester of pregnancy, with both mothers and newborns having excellent outcomes, and no evidence of intrauterine infection by vertical transmission of SARS-CoV-2.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Virology

Placental SARS-CoV-2 in a pregnant woman with mild COVID-19 disease

Albert L. Hsu et al.

Summary: A case study reported placental infection of SARS-CoV-2 in a patient with mild COVID-19 symptoms, raising concerns about placental vascular pathology and potential vertical transmission. Despite mild infection during pregnancy, there may be risks of placental vasculopathy and viral transmission across the placenta.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Obstetrics & Gynecology

Coronavirus disease 2019 infection and placental histopathology in women delivering at term

Elizabeth T. Patberg et al.

Summary: Despite neonates born to mothers with coronavirus disease 2019 testing negative for the virus, there is a significant association between the disease and placental histopathologic abnormalities, particularly fetal vascular malperfusion and villitis of unknown etiology. These findings suggest a potential impact of coronavirus disease 2019 on placental health, even in asymptomatic patients.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2021)

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Article Cell Biology

Placental Pathology Findings during and after SARS-CoV-2 Infection: Features of Villitis and Malperfusion

Thomas Menter et al.

Summary: This study presented five cases of SARS-CoV-2-positive placentas from pregnant women with mild COVID-19 symptoms or who were asymptomatic. Only one patient showed symptoms of cough and dyspnoea. Histopathological analysis revealed signs of maternal and foetal malperfusion in all placentas, but there was no evidence of transplacental transmission to the infants. The presence of SARS-CoV-2 in placental tissue and umbilical cord suggests a potential for infection of the placenta, but further research is needed to confirm this hypothesis.

PATHOBIOLOGY (2021)

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Article Acoustics

Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection

Gabriele Saccone et al.

Summary: This study evaluated the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection, finding a higher risk of ICU admission for infected mothers but a negligible risk of vertical transmission.

ULTRASOUND IN OBSTETRICS & GYNECOLOGY (2021)

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Article Obstetrics & Gynecology

Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection at the time of birth in England: national cohort study

Ipek Gurol-Urganci et al.

Summary: This study found that SARS-CoV-2 infection at the time of birth is associated with higher rates of adverse maternal and perinatal outcomes, including fetal death, preterm birth, preeclampsia, and emergency cesarean delivery. Pregnant women infected with SARS-CoV-2 should be prioritized for vaccination to reduce these risks.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2021)

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Article Medical Laboratory Technology

Chronic Histiocytic Intervillositis With Trophoblast Necrosis Is a Risk Factor Associated With Placental Infection From Coronavirus Disease 2019 (COVID-19) and Intrauterine Maternal-Fetal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission in Live-Born and Stillborn Infants

David A. Schwartz et al.

Summary: The placental pathology findings in newborns infected by transplacental transmission of SARS-CoV-2 revealed chronic histiocytic intervillositis and syncytiotrophoblast necrosis in all placentas. These findings may serve as a pathology risk factor for fetal infection in newborns infected before delivery.

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2021)

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Article Pathology

Placental pathology of the third trimester pregnant women from COVID-19

Likun Gao et al.

Summary: In this study, no evidence of vertical transmission of SARS-CoV-2 and adverse maternal-fetal outcomes were found in the placentas of third trimester pregnant women with COVID-19. The placentas showed features of maternal vascular malperfusion, providing further information for clinical management. Further studies are needed for pregnant women infected with COVID-19 in different stages of gestation, especially in the first and second trimester.

DIAGNOSTIC PATHOLOGY (2021)

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Review Biotechnology & Applied Microbiology

COVID-19: Virology, biology and novel laboratory diagnosis

Malihe Mohamadian et al.

Summary: The novel coronavirus SARS-CoV-2 has caused a global health crisis, with millions of cases and over a million deaths reported. Patients infected with SARS-CoV-2 typically present with severe viral pneumonia and to date, there is no approved vaccine or preventive treatment available. The virus enters respiratory cells via the angiotensin-converting enzyme receptor 2, with structural proteins playing a crucial role in releasing virus particles from host cells.

JOURNAL OF GENE MEDICINE (2021)

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Article Obstetrics & Gynecology

Case series of 20 pregnant women with 2019 novel coronavirus disease in Wuhan, China

Yuping Guo et al.

Summary: This study evaluated perinatal outcomes and vertical transmission potential of COVID-19 in 20 pregnant patients. The results showed that COVID-19 had no short-term adverse effect on pregnant women except for premature birth, and there was no vertical transmission of SARS-CoV-2 detected in the study.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (2021)

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Review Developmental Biology

SARS-CoV-2 placentitis: An uncommon complication of maternal COVID-19

Laura Linehan et al.

Summary: SARS-CoV-2 infection during pregnancy can lead to placental infection, posing a threat to the fetus, though this situation is relatively rare.

PLACENTA (2021)

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Article Obstetrics & Gynecology

Effect of SARS-CoV-2 infection during the second half of pregnancy on fetal growth and hemodynamics: A prospective study

Giuseppe Rizzo et al.

Summary: Pregnancies complicated by SARS-CoV-2 infection do not have a higher risk of fetal growth restriction through impaired placental function, and increased fetal surveillance is not supported based on the findings from this study.

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA (2021)

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Article Medical Laboratory Technology

Histologic and Immunohistochemical Evaluation of 65 Placentas From Women With Polymerase Chain Reaction-Proven Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

Daniel Levitan et al.

Summary: In pregnant women with SARS-CoV-2 infection, there is no characteristic histopathology in most placentas, and direct placental involvement by the virus is a rare event.

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2021)

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Article Pathology

Trophoblast damage with acute and chronic intervillositis: disruption of the placental barrier by severe acute respiratory syndrome coronavirus 2

Larisa Debelenko et al.

Summary: The placental infection rate of SARS-CoV-2 in pregnant women is low, and the virus mainly affects the syncytiotrophoblast, causing fibrin deposition and mixed intervillositis. There is no evidence of vertical transmission to the fetus.

HUMAN PATHOLOGY (2021)

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Review Virology

Being pregnant in the COVID-19 pandemic: Effects on the placenta in all aspects

C. Merve Seymen

Summary: The coronavirus disease 2019 (COVID-19) poses potential risks to the placenta, with ACE2 and TMPRSS2 expressed in the placenta potentially facilitating virus entry; current research has shown that the virus can cause histopathological changes in the placenta.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Virology

Fetal and placental infection with SARS-CoV-2 in early pregnancy

Maria Y. Valdespino-Vazquez et al.

Summary: The study found that congenital SARS-CoV-2 infection is possible during the first trimester of pregnancy, leading to damage in placenta and fetal organs, with organs like lungs and kidneys being specific targets for the coronavirus.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Obstetrics & Gynecology

Maternal and perinatal outcomes and placental pathologic examination of 29 SARS-CoV-2 infected patients in the third trimester of gestation

Luis Blasco Santana et al.

Summary: The pathological features of placentas from SARS-CoV-2 infected mothers do not show significant differences compared to normal placentas. There is currently no conclusive evidence of vertical transmission, and the presence of viral RNA in placental tissue has not been consistently demonstrated.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (2021)

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Article Developmental Biology

Placental pathology in COVID-19 affected pregnant women: A prospective case-control study

Chiara Tasca et al.

Summary: In this study, SARS-CoV-2 infection during pregnancy did not affect placental histological patterns. Pharmacological treatments and oxygen therapy administered to infected women could impact maternal and fetal outcomes and be associated with placental histological alterations.

PLACENTA (2021)

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Review Acoustics

Counseling in maternal-fetal medicine: SARS-CoV-2 infection in pregnancy

D. Di Mascio et al.

Summary: Pregnant women infected with SARS-CoV-2 may experience severe complications, including pneumonia, and should continue to receive medical care and consider vaccination during pregnancy.

ULTRASOUND IN OBSTETRICS & GYNECOLOGY (2021)

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Article Pathology

Placenta histopathology in SARS-CoV-2 infection: analysis of a consecutive series and comparison with control cohorts

Luca Bertero et al.

Summary: The study found that placentas delivered by women with COVID-19 showed certain pathological characteristics, which may be associated with the pathogenesis of the disease. While some changes remained statistically significant before and after cesarean section, careful consideration of potential confounders is necessary in future studies exploring the relationship between COVID-19 and pregnancy.

VIRCHOWS ARCHIV (2021)

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Article Virology

SARS-CoV-2 and Placenta: New Insights and Perspectives

Leonardo Resta et al.

Summary: The study on SARS-CoV-2 positive pregnant women reveals specific histopathological changes associated with the virus, such as decidual arteriopathy, decidual inflammation, perivillous fibrin deposition, and fetal vessel thrombi, which are more frequent in cases compared to controls. As the pandemic continues, further research is needed to understand the potential mechanisms of maternal-fetal transmission of the virus.

VIRUSES-BASEL (2021)

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Article Microbiology

Molecular Pathology Analysis of SARS-CoV-2 in Syncytiotrophoblast and Hofbauer Cells in Placenta from a Pregnant Woman and Fetus with COVID-19

Denise Morotti et al.

Summary: Infection of neonates by SARS-CoV-2 through intrauterine transmission from mothers is rare but possible. Placental abnormalities may be present, but the role of Hofbauer cells in SARS-CoV-2 infection is still unclear. A study found no evidence of SARS-CoV-2 infection in Hofbauer cells from a transmitting placenta.

PATHOGENS (2021)

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Article Immunology

Association Between COVID-19 Pregnant Women Symptoms Severity and Placental Morphologic Features

Patricia Zadorosnei Rebutini et al.

Summary: This study compared the placental morphological and morphometric changes in pregnant women infected with SARS-CoV-2 with those of non-infected pregnant women. The results showed that symptomatic women in the COVID-19 group were more likely to have adverse fetal outcomes, with more frequent histopathologic findings of maternal and fetal vascular malperfusion. There were no significant differences in morphometric changes between the COVID-19 group and the Control group, except for slightly more accentuated deposition of villous fibrin in the COVID-19 group.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Obstetrics & Gynecology

Pregnant women's perspectives on severe acute respiratory syndrome coronavirus 2 vaccine

Luigi Carbone et al.

Summary: The majority of pregnant women in Italy are hesitant to receive the COVID-19 vaccine during pregnancy, even though they are generally in favor of vaccines. Pregnancy is considered a key factor in the decision to refuse vaccine prophylaxis.

AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM (2021)

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Article Obstetrics & Gynecology

Maternal and perinatal outcomes in high compared to low risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection (phase 2): the World Association of Perinatal Medicine working group on coronavirus disease 2019

Francesco D'Antonio et al.

Summary: This study evaluated maternal and perinatal outcomes in pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection, finding that high-risk pregnancies were at higher risk of adverse maternal outcomes compared to low-risk pregnancies.

AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM (2021)

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Article Pediatrics

Clinical Characteristics of Mother-Infant Dyad and Placental Pathology in COVID-19 Cases in Predominantly African American Population

Sanket Jani et al.

Summary: In this study, it was found that COVID-19 does not appear to increase morbidity and mortality among pregnant women and their neonates in a predominantly AA population. There was no evidence of vertical transmission of COVID-19 infection found, and no specific findings on placental pathology were identified in any of the 34 placentas studied.

AJP REPORTS (2021)

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Review Obstetrics & Gynecology

Risk factors for abnormally invasive placenta: a systematic review and meta-analysis

Antonia Iacovelli et al.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2020)

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Article Immunology

A Case of 2019 Novel Coronavirus in a Pregnant Woman With Preterm Delivery

Xiaotong Wang et al.

CLINICAL INFECTIOUS DISEASES (2020)

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Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

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Article Pathology

Placental Pathology in COVID-19

Elisheva D. Shanes et al.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2020)

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Article Obstetrics & Gynecology

Clinical characteristics of 46 pregnant women with a severe acute respiratory syndrome coronavirus 2 infection in Washington State

Erica M. Lokken et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2020)

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Editorial Material Obstetrics & Gynecology

Visualization of severe acute respiratory syndrome coronavirus 2 invading the human placenta using electron microscopy

Gabriela N. Algarroba et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2020)

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Editorial Material Medicine, General & Internal

Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection

Maksim Kirtsman et al.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2020)

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Article Immunology

A Case Report of Neonatal 2019 Coronavirus Disease in China

Shaoshuai Wang et al.

CLINICAL INFECTIOUS DISEASES (2020)

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Letter Medicine, General & Internal

Second-Trimester Miscarriage in a Pregnant Woman With SARS-CoV-2 Infection

David Baud et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Virology

Vaginal delivery report of a healthy neonate born to a convalescent mother with COVID--19

Xiali Xiong et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Article Virology

Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia

Siyu Chen et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Article Public, Environmental & Occupational Health

Unlikely SARS-CoV-2 vertical transmission from mother to child: A case report

Zhoujie Peng et al.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2020)

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Article Pathology

Placental Pathology in Covid-19 Positive Mothers: Preliminary Findings

Rebecca N. Baergen et al.

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY (2020)

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Article Pathology

Analysis of complement deposition and viral RNA in placentas of COVID-19 patients

J. Justin Mulvey et al.

ANNALS OF DIAGNOSTIC PATHOLOGY (2020)

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Editorial Material Infectious Diseases

Vertical transmission of SARS-CoV-2 infection and preterm birth

Bianca Pulinx et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2020)

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Pregnancy and postpartum outcomes in a universally tested population for SARS-CoV-2 in New York City: a prospective cohort study

M. Prabhu et al.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2020)

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Article Cell Biology

Third-trimester placentas of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive women: histomorphology, including viral immunohistochemistry andin-situhybridization

Marie C. Smithgall et al.

HISTOPATHOLOGY (2020)

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Report of Positive Placental Swabs for SARS-CoV-2 in an Asymptomatic Pregnant Woman with COVID-19

Antonella Ferraiolo et al.

MEDICINA-LITHUANIA (2020)

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Article Pathology

SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers

Jonathon L. Hecht et al.

MODERN PATHOLOGY (2020)

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Article Immunology

Intrauterine Transmission of SARS-COV-2 Infection in a Preterm Infant

Julide Sisman et al.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2020)

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Article Multidisciplinary Sciences

Transplacental transmission of SARS-CoV-2 infection

Alexandre J. Vivanti et al.

NATURE COMMUNICATIONS (2020)

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Article Medicine, Research & Experimental

SARS-CoV-2 infection of the placenta

Hillary Hosier et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Obstetrics & Gynecology

Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19

Daniele Di Mascio et al.

JOURNAL OF PERINATAL MEDICINE (2020)

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Article Developmental Biology

Consistent localization of SARS-CoV-2 spike glycoprotein and ACE2 over TMPRSS2 predominance in placental villi of 15 COVID-19 positive maternal-fetal dyads

Elizabeth Taglauer et al.

PLACENTA (2020)

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Article Acoustics

COVID-19 during pregnancy: non-reassuring fetal heart rate, placental pathology and coagulopathy

J. E. Mongula et al.

ULTRASOUND IN OBSTETRICS & GYNECOLOGY (2020)

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Article Medicine, General & Internal

SARS-CoV2 vertical transmission with adverse effects on the newborn revealed through integrated immunohistochemical, electron microscopy and molecular analyses of Placenta

Fabio Facchetti et al.

EBIOMEDICINE (2020)

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Placental abruption in a twin pregnancy at 32 weeks' gestation complicated by coronavirus disease 2019 without vertical transmission to the babies

Katy Kuhrt et al.

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Guidelines for Pregnancy Management During the COVID-19 Pandemic: A Public Health Conundrum

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INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

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A structured review of placental morphology and histopathological lesions associated with SARS-CoV-2 infection

Megan C. Sharps et al.

PLACENTA (2020)

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Histopathologic evaluation of placentas after diagnosis of maternal severe acute respiratory syndrome coronavirus 2 infection

Moti Gulersen et al.

AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM (2020)

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Letter Obstetrics & Gynecology

Vertical transmission of coronavirus disease 2019: severe acute respiratory syndrome coronavirus 2 RNA on the fetal side of the placenta in pregnancies with coronavirus disease 2019-positive mothers and neonates at birth

Luisa Patane et al.

AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM (2020)

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Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis

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Methodological quality and synthesis of case series and case reports

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BMJ EVIDENCE-BASED MEDICINE (2018)

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Sampling and Definitions of Placental Lesions Amsterdam Placental Workshop Group Consensus Statement

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Placental histopathology after SARS-CoV-2 infection in pregnancy: a systematic review and meta-analysis

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