Journal
CHINESE JOURNAL OF NATURAL MEDICINES
Volume 19, Issue 9, Pages 641-647Publisher
CHINESE JOURNAL NATURAL MEDICINES
DOI: 10.1016/S1875-5364(21)60097-3
Keywords
Betulinic acid; Natural products; Structural modification; Derivatives; Antitumor activity
Ask authors/readers for more resources
This review summarizes the current studies of the structural diversity of antitumor betulinic acid (BA) derivatives within the last five years, which provides prospects for further research on the structural modification of betulinic acid.
Natural products are one of the important sources for the discovery of new drugs. Betulinic acid (BA), a pentacyclic triterpenoid widely distributed in the plant kingdom, exhibits powerful biological effects, including antitumor activity against various types of cancer cells. A considerable number of BA derivatives have been designed and prepared to remove their disadvantages, such as poor water solubility and low bioavailability. This review summarizes the current studies of the structural diversity of antitumor BA derivatives within the last five years, which provides prospects for further research on the structural modification of betulinic acid.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available