Journal
CHEMICAL COMMUNICATIONS
Volume 57, Issue 85, Pages 11189-11192Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1cc04669a
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Funding
- College of Arts and Sciences at Cornell University
- NSF [CHE-1531632]
- DOE Office of Science [DE-AC02-06CH11357]
- Australian Research Council [DP210102148]
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The photophysical and photochemical properties of two Pt(iv)Re(i) conjugates were studied and found to exhibit modest photocytotoxicity against ovarian cancer cells. X-ray fluorescence microscopy revealed colocalization of Pt and Re in cells, whether or not they had been irradiated. This work highlights the potential of photoactivated multilimetallic agents for cancer treatment.
The photophysical and photochemical properties of two Pt(iv)Re(i) conjugates were studied via both experimental and computational methods. Both conjugates exhibit modest photocytotoxicity against ovarian cancer cells. X-ray fluorescence microscopy showed that Pt and Re colocalize in cells whether they had been irradiated or not. This work demonstrates the potential of photoactivated multilimetallic agents for combating cancer.
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