Long Non-Coding RNA NRON promotes Tumor Proliferation by regulating ALKBH5 and Nanog in Gastric Cancer

Long non-coding RNAs (lncRNAs) act as tumor suppressors or oncogenes in tumor development and progression. In this study, we explored the expression and biological role of lncRNA NRON in gastric cancer (GC). We observed that lncNRON was upregulated in GC tissues and cell lines, and high lncNRON expression was associated with malignant features and poor prognosis in GC patients. LncNRON was found to promote the proliferation and tumorigenicity of GC cells. Mechanistically, lncNRON exerted its oncogenic functions by binding to the N6-methyladenosine eraser ALKHBS and mediating Nanog mRNA decay. In conclusion, our results suggest that IncNRON serves as an oncogenic lncRNA in GC and thus may be a promising prognostic factor and potential therapeutic target for GC patients.

Automated summary

lncRNA NRON is upregulated in gastric cancer, associated with malignant features and poor prognosis, promoting proliferation and tumorigenesis of GC cells by binding to ALKHBS and mediating Nanog mRNA decay. Its overexpression suggests NRON could be a potential therapeutic target for GC patients.