Journal
CELL TRANSPLANTATION
Volume 30, Issue -, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/09636897211051382
Keywords
mechanosensitive; non-coding RNAs; osteogenesis; mesenchymal stem cells
Funding
- National Natural Science Foundation of China [81771048, 81900981]
- China Postdoctoral Science Foundation [2019M663530]
- Sichuan Science and Technology Program [2020YFS0170, 2021YJ0149]
- Research and Development Foundation of West China Hospital of Stomatology [RD-02-201904]
- West China School/Hospital of Stomatology Sichuan University [RCDWJS2020-18]
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This review focuses on the role of mechanosensitive ncRNAs in the osteogenesis of MSCs, summarizes the signaling pathway networks by which these ncRNAs drive cell fate, and points out the limitations and areas waiting for further exploration in this field.
In bone tissue engineering, tailored biomaterials mimicking mesenchymal stem cells (MSCs) niche could regulate cell behavior and fate decision. The mechanisms, however, remain obscure. Recently, increasing evidence has shown that non-coding RNAs (ncRNAs) are critical modulators of the mechano-induced MSCs' responses. Mechanosensitive ncRNAs could convert various physical forces into biochemical signals, and orchestrate signaling networks that regulate the osteogenic differentiation of MSCs in their unique microenvironment. In this review, we focus on the mechanosensitive ncRNAs which could interpret mechanical stimuli during the osteogenesis of MSCs, summarize the signaling pathway networks by which these ncRNAs drive MSCs fate, and point out the limitations and the areas waiting for further exploration.
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