4.6 Article

Dual-functional gold-iron oxide core-satellite hybrid nanoparticles for sensitivity enhancement in biosensors via nanoplasmonic and preconcentration effects

Journal

ANALYST
Volume 146, Issue 22, Pages 6935-6943

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1an01334c

Keywords

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Funding

  1. Ministry of Science and Technology, Taiwan [MOST 108-2119-M-194002, MOST 109-2123-M-194-001]

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A dual-functional gold-iron oxide core-satellite hybrid nanoparticle structure is proposed as a signal reporter and preconcentrator for low abundance analytes in a nanoplasmonic biosensor, demonstrating an 18-fold improvement in limit of detection for detecting DNA compared to traditional methods. This easy-to-prepare structure shows promise for high-sensitivity and low-cost point-of-care applications.
A common strategy to improve the sensitivity of a biosensor for the detection of a low abundance analyte is to preconcentrate the analyte molecules before detection. A dual-functional gold-iron oxide core-satellite hybrid nanoparticle structure is proposed in this work to overcome the drawbacks of traditional sample pretreatment methods and the methods using non-magnetic nanomaterials for sample pretreatment. The new dual-functional hybrid nanoparticle structure can simultaneously serve as a signal reporter of a biorecognition event and a preconcentrator of a target at an extremely low concentration in a nanoplasmonic biosensor. By utilizing a fiber optic nanogold-linked sorbent assay in the fiber optic particle plasmon resonance (FOPPR) biosensor and an arbitrary DNA sequence as a target, we have demonstrated that the use of the new hybrid nanoparticle structure with magnetic preconcentration improves the limit of detection (LOD) for the DNA by 18 times as compared to the same method without magnetic preconcentration, so that the LOD for detecting the DNA can be as low as 2.6 fM. The new hybrid nanoparticle structure is easy to prepare and its use in the high-sensitivity and low-cost FOPPR biosensor provides vast opportunities in point-of-care applications.

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