Journal
AGING AND DISEASE
Volume 12, Issue 7, Pages 1644-1657Publisher
INT SOC AGING & DISEASE
DOI: 10.14336/AD.2021.0325
Keywords
rehabilitation; neuroplasticity; neuron; microglia; interaction
Categories
Funding
- National Natural Science Foundation of China [81802231, 81871838, 82002382]
- Organization Department of Beijing talents project [2018000082595G485]
- Laboratory Development Funds of Luhe Hospital
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Physical exercise has been shown to induce remodeling and proliferation of astrocytes, which potentially affect the recruitment and function of neurons. The interactions between astrocytes, microglia, and neurons may enhance neuroplasticity, ultimately impacting neural circuit function.
Physical exercise is an effective therapy for neurorehabilitation. Exercise has been shown to induce remodeling and proliferation of astrocyte. Astrocytes potentially affect the recruitment and function of neurons; they could intensify responses of neurons and bring more neurons for the process of neuroplasticity. Interactions between astrocytes, microglia and neurons modulate neuroplasticity and, subsequently, neural circuit function. These cellular interactions promote the number and function of synapses, neurogenesis, and cerebrovascular remodeling. However, the roles and crosstalk of astrocytes with neurons and microglia and any subsequent neuroplastic effects have not been studied extensively in exercise-induced settings. This article discusses the impact of physical exercise on astrocyte proliferation and highlights the interplay between astrocytes, microglia and neurons. The crosstalk between these cells may enhance neuroplasticity, leading to the neuroplastic effects of exercise.
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