Journal
SMALL STRUCTURES
Volume 2, Issue 10, Pages -Publisher
WILEY
DOI: 10.1002/sstr.202100094
Keywords
photoacoustic imaging; photodynamic therapy; photothermal therapy; Pt(II); synergistic phototherapy
Funding
- National Natural Science Foundation of China [22075148]
- National Funds for Distinguished Young Scientists [61825503]
- National Key Research and Development Program of China [2017YFA0205302]
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In this study, a new NIR SPT agent APIDNs was designed and synthesized for synergistic PDT and PTT effects in inhibiting tumor cell growth in vivo, demonstrating superior therapy effects and negligible dark cytotoxicity. This novel strategy offers a new way to design new-generation NIR aza-metal-dipyrromethene-based dyes for developing superior SPT agents.
The development of innovative synergistic phototherapy (SPT) agent with excellent photodynamic therapy (PDT) and photothermal therapy (PTT) effects for efficient antitumor is of great significance. However, the low photothermal conversion efficiency or low singlet oxygen yield of SPT agent during the phototherapy process will result in inefficient tumor therapy. Herein, a new near-infrared (NIR) SPT agent based on aza-platinum-dipyrromethene dye (D-3) with synergistic PDT and PTT effects is rationally designed and synthesized by the metallization and halogenation of aza-dipyrromethene simultaneously. The introduction of iodine atoms and Pt(II) ion to aza-dipyrromethene skeleton can not only effectively promote the excited electrons to undergo intersystem crossing process for improving singlet oxygen (O-1(2)) generation capability, but also inhibit radiative transition process for boosting photothermal conversion properties. For biological exploration, the biocompatible D-3 nanomaterials (APIDNs) with excellent concentration-dependent photoacoustic and photothermal properties are prepared, thus visibly guiding synergetic PDT and PTT effects for inhibiting the growth of tumor cells in vivo. This work demonstrates the superior therapy effects of APIDNs and its negligible dark cytotoxicity. The novel strategy reported in this work will offer a new way to design new-generation NIR aza-metal-dipyrromethene-based dyes for developing superior SPT agents.
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