Journal
EUROPEAN HEART JOURNAL
Volume 38, Issue 29, Pages 2290-+Publisher
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehx263
Keywords
Traffic noise; Air pollution; Systemic inflammation; Blood lipids; Blood glucose
Categories
Funding
- European Union Seventh Framework Programme (FP7) Biobank Standardisation and Harmonisation for Research Excellence in the European Union-BioSHaRE-EU [261433]
- strategic award from UK Medical Research Council (MRC)
- Wellcome Trust underpinning the ALSPAC (Avon Longitudinal Study of Parents and Children) project
- MRC, BBMRI-LPC (EU-FP7, I3 grant)
- Netherlands Organization of Scientific Research NWO [175.010.2007.006]
- Ministry of Economic Affairs
- Ministry of Education, Culture and Science
- Ministry for Health, Welfare and Sports
- Northern Netherlands Collaboration of Provinces (SNN)
- Province of Groningen
- University Medical Center Groningen
- University of Groningen
- Dutch Kidney Foundation
- Dutch Diabetes Research Foundation
- European Community's Seventh Framework Program (FP7) [211250]
- UK Medical Research Council and Public Health England [MR/L01341X/1]
- Medical Research Council [MR/L01632X/1]
- Early-Career Research Fellowship by the UK Medical Research Council-Public Health England Centre for Environment and Health [MR/M501669/1]
- Medical Research Council [MR/L01632X/1, MR/M501633/2, MR/K007017/1, UKDRI-5001, MC_PC_13040, MR/M501669/1, MR/K006525/1, G0801056, MR/L01341X/1, MR/M501633/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10136] Funding Source: researchfish
- MRC [MR/M501669/1, MR/L01632X/1, MR/M501633/1, UKDRI-5001, MR/L01341X/1, MR/K006525/1, MR/K007017/1, G0801056, MR/M501633/2] Funding Source: UKRI
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Aims Blood biochemistry may provide information on associations between road traffic noise, air pollution, and cardiovascular disease risk. We evaluated this in two large European cohorts (HUNT3, Lifelines). Methods and results Road traffic noise exposure was modelled for 2009 using a simplified version of the Common Noise Assessment Methods in Europe (CNOSSOS-EU). Annual ambient air pollution (PM10, NO2) at residence was estimated for 2007 using a Land Use Regression model. The statistical platform DataSHIELD was used to pool data from 144 082 participants aged >= 20 years to enable individual-level analysis. Generalized linear models were fitted to assess cross-sectional associations between pollutants and high-sensitivity C-reactive protein (hsCRP), blood lipids and for (Lifelines only) fasting blood glucose, for samples taken during recruitment in 2006-2013. Pooling both cohorts, an inter-quartile range (IQR) higher day-time noise (5.1 dB(A)) was associated with 1.1% [95% confidence interval (95% CI: 0.02-2.2%)] higher hsCRP, 0.7% (95% CI: 0.3-1.1%) higher triglycerides, and 0.5% (95% CI: 0.3-0.7%) higher high-density lipoprotein (HDL); only the association with HDL was robust to adjustment for air pollution. An IQR higher PM10 (2.0 mu g/m(3)) or NO2 (7.4 mu g/m(3)) was associated with higher triglycerides (1.9%, 95% CI: 1.5-2.4% and 2.2%, 95% CI: 1.6-2.7%), independent of adjustment for noise. Additionally for NO2, a significant association with hsCRP (1.9%, 95% CI: 0.5-3.3%) was seen. In Lifelines, an IQR higher noise (4.2 dB(A)) and PM10 (2.4 mu g/m(3)) was associated with 0.2% (95% CI: 0.1-0.3%) and 0.6% (95% CI: 0.4-0.7%) higher fasting glucose respectively, with both remaining robust to adjustment for air/noise pollution. Conclusion Long-term exposures to road traffic noise and ambient air pollution were associated with blood biochemistry, providing a possible link between road traffic noise/air pollution and cardio-metabolic disease risk.
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