Towards the Standardization of Flow Chemistry Protocols for Organic Reactions

Flow chemistry studies can sometimes be difficult to reproduce. In this article we provide guidance to scientists for experimental details that should be considered as part of any organic chemistry-based continuous flow study. A focus is placed on information that should be provided within reported studies to enable experiments to be more easily and reliably reproduced. Topics covered include flow reactor components and assembly, important parameter effects and useful performance criteria. The article covers aspects of homogeneous systems, multiphase transformations, and catalytic reactions (homogeneous and heterogeneous). A more detailed discussion of photochemistry, biocatalysis and electrochemical flow systems is outside the scope of this review.

Automated summary

This article provides guidance on reproducing flow chemistry studies, emphasizing the importance of providing detailed information in reported studies to enable easier and more reliable replication of experiments. The topics covered include flow reactor components, parameter effects, and performance criteria for homogeneous and heterogeneous catalytic reactions.