Copper-catalyzed C(sp)-C(sp2) oxidative cross coupling reaction to access to methyl arylpropiolates at room temperature

The first and environmentally benign oxidative cross coupling of stable trimethylsilylalkynoate with different arylboronic acids was developed. This reaction proceeded efficiently in the presence of Cu(OAc)(2) at room tem-perature through the activation of Si-C bond by catalytic Cs2CO3, providing various methyl arylpropiolates in good yields with a broad substrate scope under mild conditions.

Automated summary

The study successfully demonstrated an environmentally friendly method for the oxidative cross coupling of stable trimethylsilylalkynoate with different arylboronic acids, yielding the desired products. The reaction conditions are mild, with a broad substrate scope, making it an efficient synthetic method.