4.6 Article

Upregulation of pulmonary tissue factor, loss of thrombomodulin and immunothrombosis in SARS-CoV-2 infection

Related references

Note: Only part of the references are listed.
Article Peripheral Vascular Disease

Microvascular dysfunction in COVID-19: the MYSTIC study

Alexandros Rovas et al.

Summary: Our study found that COVID-19 patients have reduced microvascular density, slower red blood cell velocity, and glycocalyx damage. Elevated markers of endothelial dysfunction are associated with disease severity and can predict 60-day in-hospital mortality.

ANGIOGENESIS (2021)

Article Peripheral Vascular Disease

Circulating Von Willebrand factor and high molecular weight multimers as markers of endothelial injury predict COVID-19 in-hospital mortality

Aurelien Philippe et al.

Summary: This study examined the correlation between endothelial dysfunction and in-hospital mortality in COVID-19 patients. Results showed that levels of various endothelial biomarkers were elevated in critically ill patients, particularly Von Willebrand factor antigen (VWF:Ag) and high molecular weight multimers (HMWM). VWF:Ag was identified as the best predictor for in-hospital mortality among all endothelial biomarkers measured.

ANGIOGENESIS (2021)

Article Hematology

Patients With COVID-19 Have Elevated Levels of Circulating Extracellular Vesicle Tissue Factor Activity That Is Associated With Severity and Mortality-Brief Report

Axel Rosell et al.

Summary: The study found that COVID-19 patients have significantly higher levels of circulating EV TF activity compared to healthy controls. This increased activity was associated with disease severity, mortality, and markers like D-dimer, indicating a potential role of EV TF in driving thrombosis in COVID-19 patients.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

Article Hematology

Vascular neutrophilic inflammation and immunothrombosis distinguish severe COVID-19 from influenza pneumonia

Leo Nicolai et al.

Summary: Our study reveals that vascular neutrophil recruitment, NETosis, and subsequent immunothrombosis are typical features of severe COVID-19, but less prominent in influenza pneumonia when comparing histopathological specimens of SARS-CoV-2 with influenza-affected lungs. Activated neutrophils were typically found in physical association with monocytes.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

Article Hematology

The ADAMTS13-von Willebrand factor axis in COVID-19 patients

Ilaria Mancini et al.

Summary: Severe COVID-19 patients exhibit an increased risk of thromboembolic events, with evidence of microthrombosis in the lungs of deceased patients. The study found a significant alteration of the VWF-ADAMTS13 axis in COVID-19 patients, with an elevated VWF:Ag to ADAMTS13 activity ratio strongly associated with disease severity, enhancing the hypercoagulable state and risk of microthrombosis in these patients.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

Article Hematology

Vascular Endothelial Damage in the Pathogenesis of Organ Injury in Severe COVID-19

Annabelle Dupont et al.

Summary: The study investigated the association between endothelial damage and immune dysregulation with organ failure, thrombus formation, and death in 82 patients with COVID-19, finding a direct role of endotheliopathy in organ failure and an association between dysregulated immune response and respiratory failure, liver injury, and death. Thrombi from COVID-19 patients on extracorporeal membrane oxygenation showed increased neutrophil accumulation and neutrophil extracellular traps compared to non-COVID-19 thrombi.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

Article Hematology

COVID-19-induced endotheliitis: emerging evidence and possible therapeutic strategies

Eleonora Calabretta et al.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

Article Multidisciplinary Sciences

Thrombomodulin is essential for maintaining quiescence in vascular endothelial cells

Hemant Giri et al.

Summary: Deletion of TM in endothelial cells leads to increased basal permeability, enhanced tyrosine phosphorylation of VE-cadherin, reduced F-actin filament polymerization, increased NF-kappa B signaling, expression of inflammatory cell adhesion molecules, von Willebrand factor levels, storage, and release. Reexpression of TM construct normalized the cellular phenotype, suggesting cell-bound TM regulates expression of procoagulant, proinflammatory, and angiogenic molecules in vascular endothelial cells.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Biology

SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung

Alan E. Mast et al.

Summary: In COVID-19 patients, extensive fibrin deposition in the lungs and altered levels of circulating blood coagulation proteins suggest impaired local pathways that limit fibrin formation and promote clearance. Analysis of bronchoalveolar lavage fluid samples revealed decreased transcriptional levels related to fibrinolysis and increased levels related to coagulation, indicating enhanced coagulation propagation and reduced fibrinolysis as drivers of lung coagulopathy in COVID-19 patients.

ELIFE (2021)

Article Hematology

A neutrophil activation signature predicts critical illness and mortality in COVID-19

Matthew L. Meizlish et al.

Summary: Pathologic immune hyperactivation, particularly neutrophil activation, plays a central role in severe COVID-19, with early markers predicting clinical decompensation and higher mortality rates. These findings highlight the importance of understanding immune responses in critically ill COVID-19 patients.

BLOOD ADVANCES (2021)

Article Hematology

Dissemination of extreme levels of extracellular vesicles: tissue factor activity in patients with severe COVID-19

Christophe Guervilly et al.

Summary: The study found that EV-TF activity is notably increased in severe COVID-19 patients compared to moderate cases, and is associated with inflammation, disease severity, and thrombotic risk. Patients with severe COVID-19 exhibited a distinct coagulopathy profile with high EV-TF and EV-fibrinolytic activities. These findings support the need for preventive anticoagulation in hospitalized COVID-19 patients.

BLOOD ADVANCES (2021)

Article Hematology

Dynamic angiopoietin-2 assessment predicts survival and chronic course in hospitalized patients with COVID-19

Erica Villa et al.

Summary: This study found that angiopoietin-2 could serve as an important predictor for in-hospital mortality and nonresolving pulmonary condition in COVID-19 patients. Dynamic assessment of angiopoietin-2 levels may provide early disease prediction information.

BLOOD ADVANCES (2021)

Article Biochemistry & Molecular Biology

Lung Epithelial Cell Transcriptional Regulation as a Factor in COVID-19-associated Coagulopathies

Ethan S. Fitzgerald et al.

Summary: The research investigated how SARS-CoV-2 infection impacts the molecular basis of blood coagulation, revealing that it induces the extrinsic blood coagulation cascade and suppresses the plasminogen activation system. This may lead to diverse coagulopathies in lung and distal organ systems.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2021)

Article Biology

Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation

Florence W. J. Chioh et al.

Summary: The impact of COVID-19 on vascular health of recovered patients is significant, with elevated levels of circulating endothelial cells indicating vascular injury. The presence of proinflammatory and activated T lymphocyte-associated cytokines suggests cytokine-driven endothelial dysfunction. Effector T cells were more frequent in COVID-19 convalescents, pointing to a possible cytotoxic effector cell targeting of activated endothelial cells.

ELIFE (2021)

Article Immunology

Pulmonary Procoagulant and Innate Immune Responses in Critically Ill COVID-19 Patients

Esther J. Nossent et al.

Summary: This study evaluated the activation of host response pathways in the lung compartment of critically ill COVID-19 patients with persistent acute respiratory distress syndrome. The results showed strong local responses relating to coagulation, the complement system, cytokines, chemokines and growth factors in the bronchoalveolar compartment, with some biomarkers declining in levels at 3 to 4 weeks after mechanical ventilation initiation.

FRONTIERS IN IMMUNOLOGY (2021)

Article Immunology

Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

Aldo Bonaventura et al.

Summary: The authors suggest that SARS-CoV-2 infection induces a prothrombotic state and dysregulated immunothrombosis, leading to severe manifestations of COVID-19. They also discuss potential antithrombotic and immunomodulating drugs for treating COVID-19 patients, aiming to reduce the acute and long-term consequences of the disease by targeting immunothrombosis.

NATURE REVIEWS IMMUNOLOGY (2021)

Letter Infectious Diseases

An interactive web-based dashboard to track COVID-19 in real time

Ensheng Dong et al.

LANCET INFECTIOUS DISEASES (2020)

Article Medicine, General & Internal

Clinical Characteristics of Coronavirus Disease 2019 in China

W. Guan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Letter Hematology

Severe COVID-19 infection and thrombotic microangiopathy: success does not come easily

Eleni Gavriilaki et al.

BRITISH JOURNAL OF HAEMATOLOGY (2020)

Letter Medicine, General & Internal

Endothelial cell infection and endotheliitis in COVID-19

Zsuzsanna Varga et al.

LANCET (2020)

Article Biochemistry & Molecular Biology

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

Mingfeng Liao et al.

NATURE MEDICINE (2020)

Article Medicine, General & Internal

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

Maximilian Ackermann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Cardiac & Cardiovascular Systems

The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications

James D. McFadyen et al.

CIRCULATION RESEARCH (2020)

Article Developmental Biology

Cellular Mechanisms of NETosis

Hawa Racine Thiam et al.

Annual Review of Cell and Developmental Biology (2020)

Review Medicine, General & Internal

Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19) A Review

W. Joost Wiersinga et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Medicine, General & Internal

Vascular occlusion by neutrophil extracellular traps in COVID-19

Moritz Leppkes et al.

EBIOMEDICINE (2020)

Review Hematology

Coagulopathy in COVID-19

Toshiaki Iba et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

Letter Medicine, General & Internal

Venous Thromboembolism in Hospitalized Patients With COVID-19 Receiving Prophylactic Anticoagulation

Romsai T. Boonyasai et al.

MAYO CLINIC PROCEEDINGS (2020)

Article Pathology

In situ detection of SARS-CoV-2 in lungs and airways of patients with COVID-19

Inga-Marie Schaefer et al.

MODERN PATHOLOGY (2020)

Article Rheumatology

Emerging evidence of a COVID-19 thrombotic syndrome has treatment implications

Joan T. Merrill et al.

NATURE REVIEWS RHEUMATOLOGY (2020)

Article Medicine, Research & Experimental

Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

Panagiotis Skendros et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Immunology

SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology

Flavio Protasio Veras et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Article Immunology

Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID-19

Christophe Guervilly et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

Article Cardiac & Cardiovascular Systems

Circulating markers of angiogenesis and endotheliopathy in COVID-19

Matthew L. Meizlish et al.

PULMONARY CIRCULATION (2020)

Review Hematology

Neutrophils and NETs in modulating acute and chronic inflammation

Fernanda V. S. Castanheira et al.

BLOOD (2019)

Article Hematology

Evaluation of Global Hemostatic Assays in Response to Factor VIII Inhibitors

Ping Chen et al.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2019)

Review Hematology

Tissue Factor: An Essential Mediator of Hemostasis and Trigger of Thrombosis

Steven P. Grover et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)

Review Hematology

Tissue factor at the crossroad of coagulation and cell signaling

H. Zelaya et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2018)

Article Medicine, Research & Experimental

Neutrophil extracellular trap production contributes to pathogenesis in SIV-infected nonhuman primates

Ranjit Sivanandham et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Review Hematology

Angiopoietins and Tie2 in vascular inflammation

Samir M. Parikh

CURRENT OPINION IN HEMATOLOGY (2017)

Article Cardiac & Cardiovascular Systems

Cross Talk Pathways Between Coagulation and Inflammation

Jonathan H. Foley et al.

CIRCULATION RESEARCH (2016)

Article Hematology

Tissue factor deficiency increases alveolar hemorrhage and death in influenza A virus-infected mice

S. Antoniak et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2016)

Article Medicine, General & Internal

Disseminated intravascular coagulation

Satoshi Gando et al.

NATURE REVIEWS DISEASE PRIMERS (2016)

Article Biochemistry & Molecular Biology

Regulation of Alveolar Procoagulant Activity and Permeability in Direct Acute Lung Injury by Lung Epithelial Tissue Factor

Ciara M. Shaver et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2015)

Review Hematology

Biology of tissue factor pathway inhibitor

Jeremy P. Wood et al.

BLOOD (2014)

Review Hematology

Bronchoalveolar hemostasis in lung injury and acute respiratory distress syndrome

G. J. Glas et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2013)

Review Immunology

Thrombosis as an intravascular effector of innate immunity

Bernd Engelmann et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Review Anesthesiology

Procoagulant Activity in Hemostasis and Thrombosis: Virchow's Triad Revisited

Alisa S. Wolberg et al.

ANESTHESIA AND ANALGESIA (2012)

Article Biochemistry & Molecular Biology

Tissue factor pathway inhibitor: structure-function

George J. Broze et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2012)

Review Immunology

Protein C anticoagulant system-anti-inflammatory effects

Charles T. Esmon

SEMINARS IN IMMUNOPATHOLOGY (2012)

Article Hematology

Factor VIIa-antithrombin complexes in patients with arterial and venous thrombosis

Luca Spiezia et al.

THROMBOSIS AND HAEMOSTASIS (2010)

Review Hematology

Blood coagulation, inflammation, and malaria

Ivo M. B. Francischetti et al.

MICROCIRCULATION (2008)

Review Hematology

What does it take to make the perfect clot?

DM Monroe et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)

Article Critical Care Medicine

Protease-activated receptor signaling in the regulation of inflammation

W Ruf

CRITICAL CARE MEDICINE (2004)