Intravitreal Methotrexate

Intravitreal methotrexate (MTX) has been proven to be an effective treatment for various intraocular diseases. In this article, a comprehensive review was performed on intravitreal applications of methotrexate. Different aspects of the administration of intravitreal MTX for various clinical conditions such as intraocular tumors, proliferative vitreoretinopathy, diabetic retinopathy, age-related macular degeneration, and uveitis were reviewed and the adverse effects of intravitreal injection of MTX were discussed. The most common indications are intraocular lymphoma and uveitis. Other applications remain challenging and more studies are needed to establish the role of intravitreal MTX in the management of ocular diseases.

Automated summary

This article provides a comprehensive review of the intravitreal applications of methotrexate for treating various intraocular diseases. It discusses the efficacy, different clinical conditions, adverse effects, and emphasizes the most common indications being intraocular lymphoma and uveitis. More studies are needed to establish the role of intravitreal MTX in managing other ocular diseases.