Recent Advancements in 3D Printing and Bioprinting Methods for Cardiovascular Tissue Engineering

Recent decades have seen a plethora of regenerating new tissues in order to treat a multitude of cardiovascular diseases. Autografts, xenografts and bioengineered extracellular matrices have been employed in this endeavor. However, current limitations of xenografts and exogenous scaffolds to acquire sustainable cell viability, anti-inflammatory and non-cytotoxic effects with anti-thrombogenic properties underline the requirement for alternative bioengineered scaffolds. Herein, we sought to encompass the methods of biofabricated scaffolds via 3D printing and bioprinting, the biomaterials and bioinks recruited to create biomimicked tissues of cardiac valves and vascular networks. Experimental and computational designing approaches have also been included. Moreover, the in vivo applications of the latest studies on the treatment of cardiovascular diseases have been compiled and rigorously discussed.

Automated summary

This article summarizes the methods and challenges of using bioengineered scaffolds to treat cardiovascular diseases, including the use of 3D printing and bioprinting to create biofabricated scaffolds and the use of biomaterials. Addressing the issues related to xenografts and exogenous scaffolds, the necessity for alternative bioengineered scaffolds is emphasized.