Journal
MASS SPECTROMETRY LETTERS
Volume 12, Issue 3, Pages 76-80Publisher
KOREAN SOC MASS SPECTROMETRY
DOI: 10.5478/MSL.2021.12.3.76
Keywords
Scrub typhus; Orientia tsutsugamushi; proteomic analysis; serum
Categories
Funding
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI20C0033]
- Korea Basic Science Institute research program [C180310]
- National Research Council of Science & Technology (NST), Republic of Korea [C180310] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The shotgun proteomic analysis revealed RsmD as a potential biomarker of Orientia tsutsugamushi in the sera of scrub typhus patients.
Scrub typhus is an acute febrile disease caused by the pathogenic bacterium Orientia tsutsugamushi, belonging to the Rickettsiaceae family. The shotgun proteomic analysis was performed using the sera of scrub typhus patients to identify the proteins having their origin in O. tsutsugamushi. Three different databases approaches were used for the identification of the proteomes. We identified the RsmD, an RNA methyltransferase as the commonly detected protein from all three approaches. This protein was not detected in the sera of healthy negative controls. We believe that this protein is a potential biomarker of Orientia tsutsugamushi present in the sera of scrub typhus patients.
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