Journal
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
Volume 98, Issue 1, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jics.2021.100011
Keywords
Protein aggregation; Amyloids; Neurodegenerative diseases; Amyloidogenic inhibitors; Polymeric materials
Categories
Funding
- Science & Engineering Research Board (SERB), a statutory body of the Department of Science & Technology (DST), Government of India [EMR/2016/006282]
- Council of Scientific and Industrial Research (CSIR), Government of India
Ask authors/readers for more resources
One of the major challenges in biomedical and biopharmaceutical field is designing novel and effective anti-amyloidogenic inhibitors for numerous human pathophysiologies. Recently, polymer-based therapeutic agents have been extensively explored for their potential in the treatment of protein misfolding and aggregation, offering new opportunities for future therapeutic interventions in neurodegenerative diseases.
Nowadays, one of the major challenges in biomedical and biopharmaceutical field is designing novel and effective anti-amyloidogenic inhibitors for the treatment of various human pathophysiologies associated with protein aggregation. In this milieu, numerous small molecules, polyphenols, surfactants, nanoparticles, etc. have been extensively studied to explore their anti-amyloidogenic properties, and thus provide huge scope for them to appear as future therapeutic agents in the treatment of amyloidogenic disorders. Recently, inspired by the fascinating properties of polymers such as non-toxicity, excellent biocompatibility, tuneable architectures, controllable degradation rate, possibility of multiple interaction between amyloidogenic protein/peptide and polymer, and excellent in vivo stability, polymer-based therapeutic agents have been extensively explored in the field of protein misfolding and aggregation. This mini-review article emphasizes the recent advancements of polymeric materials in the field of protein aggregation for ameliorating neurodegenerative diseases. Finally, we conclude this mini-review by providing some viewpoints on future directions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available