Novel potentiometric sensors for determination of ondansetron hydrochloride in pure and dosage form

A new and sensitive potentiometric method has been developed and characterized for four novel sensors responsive to ondansetron hydrochloride. The potentiometric sensor method includes advancement of ondansetron hydrochloride sensors using a membrane comprised of molybdophosphoric acid (MPA) and ondansetron as an electro-active material in a polyvinylchloride (PVC) matrix membrane plasticized with di-butyl phthalate (DBPH), ortho-nitrophenyloctyl ether (O-NPOE), di-octyl phthalate (DOPH), or di-butyl phosphate (DBP). The validity of sensors in the present work has been examined, and steady and reproducible responses were obtained over the concentration ranges of 7.3 x 10(-5) to 1.0 x 10(-2), 6.6 x 10(-6) to 1.0 x 10(-2), 1.0 x 10(-5) to 1.0 x 10(-2), and 2.0 x 10(-5) to 1.0 x 10(-2) M for DBPH-, O-NPOE-, DOPH-, and DBP-ondansetron, respectively. The sensors revealed Nernstian gradients of 59.61 +/- 0.50, 57.71 +/- 0.23, 53.01 +/- 0.14, and 53.20 +/- 0.35 mV per decade individually with pH ranges of 2.5-5.5 in DBPH and 3.5-5.0 in O-NPOE electrodes, and 4.0-5.5 for both individual DOPH and DBP plasticized film-based sensors. The time responses for the sensors were 30, 32, 31, and 29 s for DBPH-, O-NPOE-, DOPH-, and DBP-ondansetron, respectively. The developed sensors also exhibited high selectivity towards ondansetron hydrochloride against different interfering species of inorganic particles with long-term stability of approximately 41, 36, 18, and multiple days for the DBPH, O-NPOE, DOPH, and DBP electrodes.

Automated summary

A new and sensitive potentiometric method has been developed for four novel sensors responsive to ondansetron hydrochloride. These sensors showed high selectivity towards ondansetron hydrochloride and exhibited stable responses with short response times.