Journal
CRITICAL CARE
Volume 25, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13054-021-03793-1
Keywords
Opioids; Critical illness; Gastrointestinal function; Gastrointestinal microbiome
Categories
Funding
- National Natural Science Foundation of China [8187081150]
- Natural Science Foundation of Shaanxi Province [21QNPY092]
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GI dysfunction is common in critical care, with opioids playing a role in its development. Opioid antagonists may be used to treat GI dysmotility in ICU settings.
Gastrointestinal (GI) dysfunction is common in the critical care setting and is highly associated with clinical outcomes. Opioids increase the risk for GI dysfunction and are frequently prescribed to reduce pain in critically ill patients. However, the role of opioids in GI function remains uncertain in the ICU. This review aims to describe the effect of opioids on GI motility, their potential risk of increasing infection and the treatment of GI dysmotility with opioid antagonists in the ICU setting.
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