Journal
CELL REPORTS MEDICINE
Volume 2, Issue 10, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.xcrm.2021.100407
Keywords
-
Categories
Funding
- German Federal Ministry of Education and Research (BMBF)
Ask authors/readers for more resources
Through deep lipidomic profiling, the features of WAT lipidome remodeling in obesity have been revealed, and a human WAT reference lipidome has been established, providing a basis for the development of WAT-specific high-throughput methods and integration of systems medicine data.
Obesity, characterized by expansion and metabolic dysregulation of white adipose tissue (WAT), has reached pandemic proportions and acts as a primer for a wide range of metabolic disorders. Remodeling of WAT lipidome in obesity and associated comorbidities can explain disease etiology and provide valuable diagnostic and prognostic markers. To support understanding of WAT lipidome remodeling at the molecular level, we provide in-depth lipidomics profiling of human subcutaneous and visceral WAT of lean and obese individuals. We generate a human WAT reference lipidome by performing tissue-tailored preanalytical and analytical workflows, which allow accurate identification and semi-absolute quantification of 1,636 and 737 lipid molecular species, respectively. Deep lipidomic profiling allows identification of main lipid (sub)classes undergoing depot-/phenotype-specific remodeling. Previously unanticipated diversity of WAT ceramides is now uncovered. AdipoAtlas reference lipidome serves as a data-rich resource for the development of WAT-specific high-throughput methods and as a scaffold for systems medicine data integration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available