Journal
JOURNAL OF CANCER
Volume 12, Issue 23, Pages 7111-7119Publisher
IVYSPRING INT PUBL
DOI: 10.7150/jca.60379
Keywords
colony stimulating factor-1; colony stimulating factor-1 receptor; tumor-associated macrophages; gastrointestinal malignant tumors
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Funding
- Education Foundation of Liaoning Province [JC2019021]
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Gastrointestinal malignant tumors are among the most common types of cancer globally, with poor prognosis for advanced patients. Research on tumor microenvironment and cytokines has become a hotspot, with CSF-1/CSF-1R playing crucial roles in regulating tumor-associated macrophages. Targeted inhibition of the CSF-1/CSF-1R signal axis shows promising prospects in cancer immunotherapy.
Gastrointestinal malignant tumor is the fourth most common cancer in the world and the second cause of cancer death. Due to the susceptibility to lymphatic metastasis and liver metastasis, the prognosis of advanced tumor patients is still poor till now. With the development of tumor molecular biology, the tumor microenvironment and the cytokines, which are closely related to the proliferation, infiltration and metastasis, have become a research hotspot in life sciences. Colony stimulating factor-1 (CSF-1), a polypeptide chain cytokine, and its receptor CSF-1R are reported to play important roles in regulating tumor-associated macrophages in tumor microenvironment and participating in the occurrence and development in diversities of cancers. Targeted inhibition of the CSF-1/CSF-1R signal axis has broad application prospects in cancer immunotherapy. Here, we reviewed the biological characters of CSF-1/CSF-1R and their relationship with gastrointestinal malignancies.
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