Journal
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
Volume 238, Issue -, Pages -Publisher
ELSEVIER GMBH
DOI: 10.1016/j.ijheh.2021.113858
Keywords
PM2.5; Eye; Satellite-based model
Funding
- National Natural Science Foundation of China [82020108007, 81830026]
- Beijing-Tianjin Hebei Special Project [19JCZDJC64300(Z)]
- National Key Research and Development Program of China [2016YFC0206503, 2017YFC0211605]
- National Institute of Environmental Health Sciences of the National Institutes of Health [1R01ES032140]
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Long-term exposure to PM2.5 was found to be associated with glaucoma and primary angle-closure glaucoma in Chinese adults, with middle-aged residents and non-smokers being more sensitive to the adverse effects of PM2.5.
Background: A growing body of evidence has confirmed the association between fine particulate matter (PM2.5) and ocular diseases, but little is known on the effect of long-term PM2.5 exposure on glaucoma. Methods: A national cross-sectional study of the Rural Epidemiology for Glaucoma was conducted in 10 provinces of China, and 33,701 adults aged 40 years or more were included. A satellite-based model at 1-km resolution level was used to estimate PM2.5 concentrations which were assigned to each participant according to geocoded home addresses. Logistic regression model was performed to investigate associations of long-term PM2.5 exposure with glaucoma and its subtypes. Results: Estimated PM2.5 concentrations ranged from 28.0 to 96.4 mu g/m(3). For each 10 mu g/m(3) increment in PM2.5, the adjusted odds ratios (ORs) were 1.07 (95% CI: 1.00-1.15) and 1.14 (95% CI: 1.02-1.26) for glaucoma and primary angle-closure glaucoma (PACG), respectively. A positive but non-significant association (OR = 1.05, 95% CI: 0.92-1.18) was detected between long-term exposure to PM2.5 and odds of primary open-angle glaucoma. The middle aged residents and non-smokers were more sensitive to the adverse effects of PM2.5. Conclusions: Long-term PM2.5 exposure was associated with glaucoma and PACG in Chinese adults, which provided new insights on adverse ophthalmic effect of PM2.5.
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