Green synthesis of nickel nanoparticles using Fumaria officinalis as a novel chemotherapeutic drug for the treatment of ovarian cancer

In the present study, nickel nanoparticles were green-synthesized using the aqueous extract of Fumaria officinalis. The synthesized NiNPs@F. officinalis were characterized by analytical techniques including EDX, FE-SEM, XRD, UV-Vis., and FT-IR. The antioxidant and anti-ovarian cancer activity of NiNPs@F. officinalis was evaluated. The nanoparticles were formed in a spherical shape in the range of 16.85 to 49.04 nm for the particle size. In the antioxidant test, the IC50 of F. officinalis, NiNPs@F. officinalis, and BHT against DPPH free radicals were 253, 145, and 107 mu g/mL, respectively. In the cellular and molecular part of the recent study, the treated cells with NiNPs@F. officinalis were assessed by MTT assay for 48 h about the cytotoxicity and anti-human ovarian cancer properties on normal (HUVEC) and ovarian cancer cell lines i.e. PA-1, Caov-3, SW-626, and SK-OV-3. The viability of malignant ovarian cell line reduced dose-dependently in the presence of NiNPs@F. officinalis. The IC50 of NiNPs@F. officinalis were 375, 225, 246, and 279 mu g/mL against PA-1, Caov-3, SW-626, and SK-OV-3 cell lines, respectively. After the clinical study, nickel nanoparticles containing F. officinalis leaf aqueous extract may be used to formulate a new chemotherapeutic drug or supplement to treat several types of human ovarian cancer.

Automated summary

In this study, nickel nanoparticles were synthesized using the aqueous extract of Fumaria officinalis and characterized by various analytical techniques. The synthesized nanoparticles showed promising antioxidant and anti-ovarian cancer activity. Results indicated that NiNPs@F. officinalis exhibited significant cytotoxicity against ovarian cancer cell lines, suggesting its potential as a therapeutic agent for human ovarian cancer.