4.5 Review

New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD)

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Summary: GVHD, both acute and chronic, is a major complication of allogeneic transplantation, and its prevention is crucial for the success of transplants. Current standards revolve around calcineurin inhibitors, but promising translational advances targeting T-cell regulation and co-stimulatory pathways are emerging. These approaches are based on a pathophysiology perspective and show potential for transforming GVHD prophylaxis in the near future.

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