4.7 Article

SenSARS: A Low-Cost Portable Electrochemical System for Ultra-Sensitive, Near Real-Time, Diagnostics of SARS-CoV-2 Infections

Journal

Publisher

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TIM.2021.3119147

Keywords

Biosensors; electrochemical biosensors; electrochemical impedance spectroscopy (EIS); SARS-CoV-2

Funding

  1. Colombian Ministry of Science, Innovation [360-2020]

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One critical step to solving the SARS-CoV-2 pandemic is to stop its spread by detecting and isolating asymptomatic individuals infected with the virus. Unfortunately, current rapid testing tools lack the ability for early detection. SenSARS is an accurate, portable, and low-cost medical device that offers real-time diagnostics and viral load tracking capabilities.
A critical path to solving the SARS-CoV-2 pandemic, without further socioeconomic impact, is to stop its spread. For this to happen, pre- or asymptomatic individuals infected with the virus need to be detected and isolated opportunely. Unfortunately, there are no current ubiquitous (i.e., ultra-sensitive, cheap, and widely available) rapid testing tools capable of early detection of SARS-CoV-2 infections. In this article, we introduce an accurate, portable, and low-cost medical device and bio-nanosensing electrode dubbed SenSARS and its experimental validation. SenSARS' device measures the electrochemical impedance spectra of a disposable bio-modified screenprinted carbon-based working electrode (SPCE) to the changes in the concentration of SARS-CoV-2 antigen molecules (S spike proteins) contained within a sub-microliter fluid sample deposited on its surface. SenSARS offers real-time diagnostics and viral load tracking capabilities. Positive and negative control tests were performed in phosphate-buffered saline (PBS) at different concentrations (between 1 and 50 fg/mL) of SARS-CoV-2(S), Epstein-Barr virus (EBV) glycoprotein gp350, and Influenza H1N1 M1 recombinant viral proteins. We demonstrate that SenSARS is easy to use, with a portable and lightweight (<200 g) instrument and disposable test electrodes (

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