Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 19, Issue 45, Pages 9946-9952Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ob01792f
Keywords
-
Categories
Funding
- Zhejiang Provincial Natural Science Foundation of China [LQ19B020003, LY21B020003]
- Jinhua Science and Technology Bureau [2021-3-150]
- Jinhua Branch of Sichuan Industrial Institute of Antibiotics [1003, SIIAJH-202002, SIIAJH-202006]
Ask authors/readers for more resources
In this study, an electron-deficient alkene embedded with an oxidizing function/leaving group was used as a rare and nontraditional C-1 synthon to achieve a redox-neutral Rh(iii)-catalyzed chemo- and regioselective [4 + 1] annulation of benzamides for the synthesis of functionalized isoindolinones. This method demonstrated a broad substrate scope, good to excellent yields, excellent chemo- and regioselectivity, good tolerance of functional groups, and mild external-oxidant-free conditions.
Herein, using electron-deficient alkenes embedded with an oxidizing function/leaving group as a rare and nontraditional C-1 synthon, we have achieved the redox-neutral Rh(iii)-catalyzed chemo- and regioselective [4 + 1] annulation of benzamides for the synthesis of functionalized isoindolinones. This method features broad substrate scope, good to excellent yields, excellent chemo- and regioselectivity, good tolerance of functional groups and mild external-oxidant-free conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available