Journal
AGGREGATE
Volume 2, Issue 3, Pages -Publisher
WILEY
DOI: 10.1002/agt2.23
Keywords
clinical translation; fluorescence imaging; intraoperative navigation; targeted fluorescent probes; tumor surgery
Funding
- National Key Research and Development Program of China [2016YFA0201400]
- State Key Program of National Natural Science of China [81930047]
- Projects of International Cooperation and Exchanges NSFC-PSF [31961143003]
- National Project for Research and Development of Major Scientific Instruments [81727803]
- Beijing Natural Science Foundation, Haidian, Original Innovation Joint Fund [17L20170]
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China [81421004]
Ask authors/readers for more resources
The rapid development of fluorescence imaging for intraoperative navigation has led to further development of targeted fluorescent probes, with some already in clinical trials. NIR-II fluorescent probes demonstrate better performance in terms of penetration depths and signal-to-background ratios, but face challenges in transitioning from bench to bedside.
The rapid development of fluorescence imaging for intraoperative navigation has spurred further development of targeted fluorescent probes in the past decade. Only a few nontargeted dyes, including indocyanine green and methylene blue, are currently applied for fluorescence guided surgery in the clinic. While no targeted fluorescent probes have been approved for the clinic, a number of them have entered clinical trials. These probes have emission wavelengths in the visible and near infrared (NIR)-I (700-900 nm) range. Among them, activatable probes and nanoprobes have generated special interest. Compared with NIR-I fluorescent probes, NIR-II (1000-1700 nm) fluorescent probes exhibit better intravital performance in terms of increased penetration depths, reduced tissue autofluorescence, and higher signal-to-background ratios. However, more challenges are expected before the successful translation of NIR-II probes from bench to bedside. This review provides a brief overview of targeted fluorescent probes under clinical evaluation and recent achievements in the field of NIR-II fluorescence imaging. In addition, we outline key considerations concerning the design of fluorescent probes for clinical translation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available