Journal
EUROPEAN HEART JOURNAL
Volume 38, Issue 30, Pages 2333-2339CPublisher
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehx343
Keywords
Retrospective radiocarbon dating; Cardiomyocyte proliferation; Dynamics of renewal
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Funding
- DFG-Center for Regenerative Therapies
- Karolinska Institutet
- Swedish Research Council
- Ragnar Soderberg Foundation
- Ake Wiberg Foundation
- Jeanssons Foundations
- NIH [1R01HL131778]
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The capacity of the mammalian heart to regenerate cardiomyocytes has been debated over the last decades. However, limitations in existing techniques to track and identify nascent cardiomyocytes have often led to inconsistent results. Radiocarbon (14C) birth dating, in combination with other quantitative strategies, allows to establish the number and age of human cardiomyocytes, making it possible to describe their age distribution and turnover dynamics. Accurate estimates of cardiomyocyte generation in the adult heart can provide the foundation for novel regenerative strategies that aim to stimulate cardiomyocyte renewal in various cardiac pathologies.
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