Journal
DALTON TRANSACTIONS
Volume 50, Issue 45, Pages 16770-16774Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1dt03495b
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Funding
- H. C. Brown Center for Borane Research
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A highly versatile synthesis of amine-boranes has been achieved through carbonyl reduction by sodium borohydride, resulting in the production of borane complexes with various amine functionalities and phosphines. This method allows for the activation of sodium borohydride using aldehydes and ketones as the carbonyl source, leading to the formation of borane reactive functionalities and heteroarylamines.
A highly versatile synthesis of amine-boranes via carbonyl reduction by sodium borohydride is described. Unlike the prior bicarbonate-mediated protocol, which proceeds via a salt metathesis reaction, the carbon dioxide-mediated synthesis proceeds via reduction to a monoformatoborohydride intermediate. This has been verified by spectroscopic analysis, and by using aldehydes and ketones as the carbonyl source for the activation of sodium borohydride. This process has been used to produce borane complexes with 1 degrees-, 2 degrees-, and 3 degrees-amines, including those with borane reactive functionalities, heteroarylamines, and a series of phosphines.
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