Journal
GENOME BIOLOGY
Volume 22, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13059-021-02515-8
Keywords
Intron retention; Splicing efficiency; RNA sequencing
Funding
- Agence Nationale de la Recherche (ANRJCJC -WIRED)
- Labex EpiGenMed
- MUSE initiative
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IRFinder-S is a specialized suite of tools for analyzing and exploring intron retention events in multiple samples, with a focus on accurately identifying true events, facilitating result sharing between labs, integrating a dynamic database for sample exploration and comparison, and providing a tested method for detecting differential levels of intron retention.
Accurate quantification and detection of intron retention levels require specialized software. Building on our previous software, we create a suite of tools called IRFinder-S, to analyze and explore intron retention events in multiple samples. Specifically, IRFinder-S allows a better identification of true intron retention events using a convolutional neural network, allows the sharing of intron retention results between labs, integrates a dynamic database to explore and contrast available samples, and provides a tested method to detect differential levels of intron retention.
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