Journal
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
Volume 19, Issue -, Pages 5622-5636Publisher
ELSEVIER
DOI: 10.1016/j.csbj.2021.10.005
Keywords
Neurite outgrowth; Axon guidance; Protein-protein interaction; NOG motif; Homophilic binding; Ig-like fold; Biomimetic peptide; Regenerative medicine; Neuronal differentiation
Funding
- Padua University [PRAT2015 CPDA151948]
- PRID Junior 2019 Project
- CaRiPaRo foundation
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The discovery of conserved protein motifs can reveal important regulatory signals, and synthetic peptides derived from such motifs can be used as biomimetics for biotechnological and therapeutic purposes. Specific Ig-like repeats from neuronal Cell Adhesion Molecules share a highly conserved Neurite Outgrowth and Guidance (NOG) motif, which can boost neurite formation.
The discovery of conserved protein motifs can, in turn, unveil important regulatory signals, and when properly designed, synthetic peptides derived from such motifs can be used as biomimetics for biotechnological and therapeutic purposes. We report here that specific Ig-like repeats from the extracellular domains of neuronal Cell Adhesion Molecules share a highly conserved Neurite Outgrowth and Guidance (NOG) motif, which mediates homo- and heterophilic interactions crucial in neural development and repair. Synthetic peptides derived from the NOG motif of such proteins can boost neuritogenesis, and this potential is also retained by peptides with recombinant sequences, when fitting the NOG sequence pattern. The NOG motif discovery not only provides one more tile to the complex puzzle of neuritogenesis, but also opens the route to new neural regeneration strategies via a tunable biomimetic toolbox. (C) 2021 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
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