Journal
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
Volume 46, Issue 5, Pages 395-413Publisher
SPRINGER
DOI: 10.1007/s00249-017-1216-8
Keywords
STIM; Orai; TRP; SPCA; Cancer; Constitutive/basal Ca2+ entry
Categories
Funding
- la Ligue Contre le Cancer (comites des regions Bretagne)
- la Ligue Contre le Cancer (Pays de la Loire, Centre)
- la Ligue Contre le Cancer (Poitou-Charentes)
- Region Centre (LIPIDS project)
- Inserm
- CNRS
- Canceropole Grand Ouest
- association CANCEN
- Tours' Hospital oncology association ACORT
- Fondation ARC
- ANR [ANR-12-JSV2-0004-001]
- Biosite University of Brest
- University of Rennes 1
- University of Poitiers
- University of Tours
- Roche-SFD
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Tight control of basal cytosolic Ca2+ concentration is essential for cell survival and to fine-tune Ca2+-dependent cell functions. A way to control this basal cytosolic Ca2+ concentration is to regulate membrane Ca2+ channels including store-operated Ca2+ channels and secondary messenger-operated channels linked to G-protein-coupled or tyrosine kinase receptor activation. Orai, with or without its reticular STIM partner and Transient Receptor Potential (TRP) proteins, were considered to be the main Ca2+ channels involved. It is well accepted that, in response to cell stimulation, opening of these Ca2+ channels contributes to Ca2+ entry and the transient increase in cytosolic Ca2+ concentration involved in intracellular signaling. However, in various experimental conditions, Ca2+ entry and/or Ca2+ currents can be recorded at rest, without application of any experimental stimulation. This led to the proposition that some plasma membrane Ca2+ channels are already open/activated in basal condition, contributing therefore to constitutive Ca2+ entry. This article focuses on direct and indirect observations supporting constitutive activity of channels belonging to the Orai and TRP families and on the mechanisms underlying their basal/constitutive activities.
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