Journal
ANALYTICAL METHODS
Volume 13, Issue 46, Pages 5549-5554Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1ay01670a
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Funding
- MIC/SCOPE [JP195006001]
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Using a compact ultra-broadband terahertz semiconductor source, spectral imaging of pharmaceutical material was demonstrated. The method allows distinguishing crystal forms of pharmaceutical materials.
Spectral imaging of pharmaceutical material using a compact ultra-broadband (1-4 THz) terahertz semiconductor source was demonstrated. False-color RGB images could be obtained using a simple procedure (calibration free). The ability to distinguish the polymorphism of carbamazepine (CBZ), the hydrate forms of d-(+)-glucose and caffeine, and the crystallinity of nifedipine was demonstrated using the THz DFG source. Crystal forms of pharmaceutical materials can be distinguished using this method.
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