Journal
DALTON TRANSACTIONS
Volume 50, Issue 46, Pages 17075-17085Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1dt02489b
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Funding
- University of Salerno (Fondo di Ateneo Ricerca di Base)
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This study investigates the interaction of a family of fluorescent zinc complexes with HS-, showing the potential of these complexes to be used as HS-/H2S fluorescent sensors and probes for detecting H2S in living cells. Computational analysis based on TD-DFT was performed to shed light on the species formed in solution and elucidate the photophysical properties of the sensing constructs. Preliminary bio-imaging experiments indicate the promising potential of this class of compounds for H2S detection in living cells.
In this work we explore the interaction of HS- with a family of fluorescent zinc complexes. In particular we selected a family of complexes with N,O-bidentate ligands aiming at assessing whether the zinc-chelating ligand plays a role in influencing the reactivity of HS- with the complexes under investigation. Different experiments, performed by diverse spectroscopic techniques, provide evidence that HS- binds the zinc center of all the complexes included in this study. The results highlight the potential of the devised systems to be used as HS-/H2S fluorescent sensors via a coordinative-based approach. To shed light on the species formed in solution when HS-/H2S interacts with the title complexes and aiming to rationalize the photophysical properties of the sensing constructs, we performed a computational analysis based on the time dependent density functional theory (TD-DFT). Preliminary bio-imaging experiments were also performed and the results indicate the potential of this class of compounds as probes for the detection of H2S in living cells.
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