3.8 Article

A Paradox in Digital Memory Assessment: Increased Sensitivity With Reduced Difficulty

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Laptop-Administered NIH Toolbox and Cogstate Brief Battery in Community-Dwelling Black Adults: Unexpected Pattern of Cognitive Performance between MCI and Healthy Controls

Anson Kairys et al.

Summary: This study examines the validity of computerized cognitive assessments in characterizing Alzheimer's disease in black adults. The results suggest that NIH Toolbox crystallized abilities may be more sensitive to diagnostic group differences, while deficits in memory and executive functioning tests also contribute to prediction.

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY (2022)

Article Neurosciences

Visual Memory Deficits in Middle-Aged APOE epsilon 4 Homozygotes Detected Using Unsupervised Cognitive Assessments

Yen Ying Lim et al.

Summary: The study found that middle-aged adults with the APOE ε4 homozygous genotype exhibit memory impairment, which increases with age, while middle-aged adults with the APOE ε4 heterozygous genotype do not show significant differences in cognition compared to non-carriers.

JOURNAL OF ALZHEIMERS DISEASE (2021)

Article Clinical Neurology

Diagnostic accuracy of the Cogstate Brief Battery for prevalent MCI and prodromal AD (MCI A+T+) in a population-based sample

Eva C. Alden et al.

Summary: The study evaluated the diagnostic accuracy of the Cogstate Brief Battery for MCI and prodromal AD in a population-based sample. The results showed that the diagnostic accuracy of CBB improved when discriminating between CU A-T- and MCI A+T+ as well as differentiating MCI participants without AD biomarkers from those with prodromal AD. However, the clinical utility of CBB for detecting MCI in a population-based sample was found to be lower than expected.

ALZHEIMERS & DEMENTIA (2021)

Article Psychiatry

Acute cognitive effects of single-dose intravenous ketamine in major depressive and posttraumatic stress disorder

Margaret T. Davis et al.

Summary: Intravenous subanesthetic doses of ketamine can reduce psychiatric distress in MDD and PTSD patients, but may temporarily impair attention, executive function, and verbal memory in both patient groups. However, these cognitive declines are transient and resolve within 1 day of ketamine administration, with no evidence of long-term cognitive dysfunction.

TRANSLATIONAL PSYCHIATRY (2021)

Article Neurosciences

Pilot Evaluation of the Unsupervised, At-Home Cogstate Brief Battery in ADNI-2

Chris J. Edgar et al.

Summary: The study evaluated the feasibility of at-home, self-completion of the CBB in the ADNI over 24 months, showing potential for use in MCI groups. However, data collection declined over time, suggesting the need for strategies to maintain compliance.

JOURNAL OF ALZHEIMERS DISEASE (2021)

Review Clinical Neurology

Current advances in digital cognitive assessment for preclinical Alzheimer's disease

Fredrik Ohman et al.

Summary: Digital cognitive assessment shows potential advantages in capturing and tracking cognitive changes in the preclinical stage of Alzheimer's disease. Current research indicates good validity of digital cognitive assessment against Alzheimer's disease biomarkers, and it is expected to play a crucial role in future screening and tracking efforts.

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING (2021)

Article Clinical Neurology

Using Digital Tools to Advance Alzheimer's Drug Trials During a Pandemic: The EU/US CTAD Task Force

Jeffrey Kaye et al.

Summary: The 2020 COVID-19 pandemic disrupted AD clinical studies globally, prompting exploration of digital technologies to enable remote assessments. While digital tools have potential to accelerate trials and reduce costs, concerns remain about data stability, validity, generalizability, and regulatory acceptance. The Task Force supports further exploration of digital technologies, emphasizing the need for standardization of digital readouts.

JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE (2021)

Review Clinical Neurology

Current State of Self-Administered Brief Computerized Cognitive Assessments for Detection of Cognitive Disorders in Older Adults: A Systematic Review

E. Tsoy et al.

Summary: A systematic review was conducted on self-administered computerized cognitive assessment measures for older adults, revealing variability in psychometric rigor and clinical applicability across different tools. Only a few measures assessed feasibility and usability in clinical settings, and gaps in scientific rigor were identified in the development and validation of these measures. Further advancements in technology and biomarker studies may provide future directions for the use of digital technology in clinical care.

JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE (2021)

Article Clinical Neurology

The Computerized Cognitive Composite (C3) in A4, an Alzheimer's Disease Secondary Prevention Trial

Kathryn V. Papp et al.

Summary: Computerized cognitive assessments, such as the tablet-based Computerized Cognitive Composite (C3), show feasibility and validity in AD prevention trials. The C3 was found to be feasible for clinically normal older adults and moderately correlated with standard cognitive measures. Additionally, individuals with A beta+ performed worse on the C3 compared to those with A beta-, indicating its potential as a sensitive cognitive outcome measure.

JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE (2021)

Article Neurosciences

Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer's Disease

Christopher Fowler et al.

Summary: The AIBL study, which started in 2006, includes both Inception and Enrichment cohorts totaling over 8,500 person-years of investigation. It has contributed significantly to the understanding of Alzheimer's disease, providing valuable data for the development of interventions to delay, prevent, or treat the disease.

JOURNAL OF ALZHEIMERS DISEASE REPORTS (2021)

Article Clinical Neurology

Validation of online functiona measures in cognitively impaired older adults

Rachel L. Nosheny et al.

ALZHEIMERS & DEMENTIA (2020)

Article Clinical Neurology

Unsupervised assessment of cognition in the Healthy Brain Project: Implications for web-based registries of individuals at risk for Alzheimer's disease

Stephanie Perin et al.

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS (2020)

Review Behavioral Sciences

Mnemonic Similarity Task: A Tool for Assessing Hippocampal Integrity

Shauna M. Stark et al.

TRENDS IN COGNITIVE SCIENCES (2019)

Article Psychology, Clinical

Using Robust Normative Data to Investigate the Neuropsychology of Cognitive Aging

Karra D. Harrington et al.

ARCHIVES OF CLINICAL NEUROPSYCHOLOGY (2017)

Review Clinical Neurology

Neuropsychological Assessment: Past and Future

Kaitlin B. Casaletto et al.

JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY (2017)

Article Computer Science, Interdisciplinary Applications

equate: An R Package for Observed-Score Linking and Equating

Anthony D. Albano

JOURNAL OF STATISTICAL SOFTWARE (2016)

Article Psychology, Multidisciplinary

The Critical Importance of Retrievaland Spacingfor Learning

Nicholas C. Soderstrom et al.

PSYCHOLOGICAL SCIENCE (2016)

Article Clinical Neurology

Performance of the CogState computerized battery in the Mayo Clinic Study on Aging

Michelle M. Mielke et al.

ALZHEIMERS & DEMENTIA (2015)

Article Pharmacology & Pharmacy

Digital Technologies for Cognitive Assessment to Accelerate Drug Development in Alzheimer's Disease

C. Leurent et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2015)

Article Multidisciplinary Sciences

Age-related memory deficits linked to circuit-specific disruptions in the hippocampus

Michael A. Yassa et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Neurosciences

Pattern separation in the hippocampus

Michael A. Yassa et al.

TRENDS IN NEUROSCIENCES (2011)

Article Public, Environmental & Occupational Health

Evaluation of the Usability of a Brief Computerized Cognitive Screening Test in Older People for Epidemiological Studies

J. Fredrickson et al.

NEUROEPIDEMIOLOGY (2010)

Article Clinical Neurology

The use of effect sizes to characterize the nature of cognitive change in psychopharmacological studies: an example with scopolamine

Amy Fredrickson et al.

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL (2008)

Article Multidisciplinary Sciences

Pattern separation in the human hippocampal CA3 and dentate gyrus

Arnold Bakker et al.

SCIENCE (2008)

Article Clinical Neurology

Imaging β-amyloid burden in aging and dementia

C. C. Rowe et al.

NEUROLOGY (2007)